Table 1. Summary of included studies.
Author, year. Country	Methods	TAI (+)	TAI (-)	Conclusions
Lukaszuk et al., 2015. China	Retrospective Cohort study of euthyroid women, age 34-35 years, submitted to IVF/ICSI between April 2010 and April 2012. Population was divided in 2 groups: patients with TPOAb+ (n=114) and TPOAb- (n=495) Measurement of TPOAb by ECLIA. Reference value: 0-34 IU/ml	Clinical Pregnancy: n=50 Miscarriage: n=3	Clinical Pregnancy: n=235 Miscarriage: n=29	IVF patients undergoing ICSI with TPOAb+ vs TPOAb- did not present statistically significant differences in fertilization, implantation, pregnancy, and live newborn rates. The presence of TPOAb did not increase the risk of miscarriage (6% vs. 12.4%, p=0.29)
Zhong et al., 2012. Poland	Retrospective cohort study of patients (mean age=32 years) submitted to IVF/ICSI between August 2009 and August 2010. Population was divided in two groups: patients with TAI [TPOAb+ and/or anti-Tg+] (n=90) and without TAI (n=676) Measurement of TAI by CMIA: -TPOAb+ ≥561UI/ml -anti-Tg+] ≥4.11UI/ml	Clinical Pregnancy: n=52 Miscarriage: n=14	Clinical Pregnancy: n=458 Miscarriage: n=54	Fertilization implantation and pregnancy rates after IVF-ET were significantly lower (64.3% vs. 74.6%, p<0.001; 17.8% vs. 27.1%, p<0.001; and 33.3% vs. 46.7%, p=0.002, respectively), whereas miscarriage rates were significantly higher (26.9% vs. 11.8%) in patients with TAI versus controls (without TAI).
Negro et al., 2007 Italy	Retrospective Cohort study of euthyroid women aged 20-35 years, carried out between January 2000 and January 2005. A total of 416 patients were selected; 42 had TPOAb+ and 374 TPOAb-. Measurement method of TPOAb by RIA: -TPOAb+ ≥100 Ku/l	Clinical Pregnancy: n=21 Miscarriage: n=5	Clinical Pregnancy: n=234 Miscarriage: n=27	In euthyroid patients, pregnancy and delivery rates were not affected by the presence of TPOAb. In patients with TPOAb+, the subgroup of patients that did not achieve pregnancy had miscarriages had higher TSH levels, but within the normal range (2.8mUI/ml) vs. patients that delivered (TSH 1.06 mUI/ml, p=0.032)
Kutteh et al., 1999 USA	Retrospective cohort study of women aged 35±4 years offered IVF in 3 centers in the USA between April 1996 and April 1997. From a total of 873 patients with ART, 143 women had TAI [TPOAb+ and/or anti-Tg+]. Results were compared to a control group of 200 non-pregnant women of childbearing age with no record of reproductive problems Measurement of AIT with ELISA: -TPOAb+ ≥65 UI/ml. -anti-Tg+ ≥120 UI/ml.	Clinical Pregnancy n=87 Miscarriage: n=9	Clinical Pregnancy: n=444 Miscarriage: n=48	The presence of TAI was similar between patients offered ART and controls (16.4% vs. 14.5 %, OR: 1.16) No statistically significant differences were found in delivery (54.5% vs. 54.2%,p=1.00), biochemical miscarriage (3.5% vs. 4.7%, p=0.66), clinical miscarriage (6.3% vs. 6.6%, p=1.00), and pregnancy failure (35.7% vs. 34.5%, p=0.85) rates between patients with and without TAI.