Table 1. Effect of aqueous extract of Senecio biafrae leaves on body and organ weight of adult male Sprague Dawley rats with tetracycline-induced infertility after 28 days of administration
Parameters Groups
A B C D E F
Initial body weight (g) 213.8±3.04 209.8±1.38 207.0±1.53 208.0±1.24 214.3±4.19 211.3±3.05
Final body weight (g) 225.5±3.09 215.9±2.54 249.9±6.65α 277.1±7.91α 256.2±7.22α 222.6±3.01
Body weight difference (g) 11.7± 0.05 6.1±1.26 42.9±5.12α 69.1±6.67α 41.9±3.03α 11.3±0.04
Testis 0.84±0.02 0.68±0.04β 0.81±0.02 0.74±0.02 0.80±0.02** 1.90±0.02**
Epididymis 0.27±0.08 0.05±0.00β 0.12±0.05 0.33±0.05 0.36±0.06** 0.26±0.08
Seminal Vesicle 0.40±0.02 0.16±0.05β 0.40±0.04 0.36±0.02 0.37±0.02** 0.33±0.05**
Values are expressed as Mean ± S.E.M, n=6 in each group
α: significantly greater than control group at p<0.05
β: significantly lower than control group
**: significantly dissimilar from group B One-Way ANOVA.
The organo-somatic index (OSI) was expressed as a percentage of the total body weight in relation to the weight of the target organs, OSI = (Organ weight/total body weight) × 100.
A (Control): 2ml/kg of body weight of normal saline
B: 30 mg/kg of body weight of Tetracycline
C: 30 mg/kg of body weight of Tetracycline and 50 mg/kg of body weight of vitamin C
D: 30 mg/kg of body weight of Tetracycline and 500 mg/kg of body weight of Senecio biafrae extract
E: 30 mg/kg of body weight of Tetracycline + 50 mg/kg of body weight of vitamin C + 500 mg/kg of body weight of Senecio biafrae extract
F: 30 mg/kg of body weight of Tetracycline reversal