| Table 1. Summary of studies included | |||||
| Study | Type of study | Outcome | Inclusion criteria | Exposure | Pregnancies |
|---|---|---|---|---|---|
| Barad et al., 2007 | Case control | Mean number of oocytes recovery Implantation rate Clinical Pregnancy rate Abortion rate |
FSH >12mIU/ml E2≥75pg/ml |
25mg tid for 4 months | DHEA group: 13/64 pregnancies Control group: 11/101 pregnancies |
| Wiser et al., 2010 | Randomized controlled trial | Mean number of oocytes recovery Clinical Pregnancy rate Abortion rate |
Previous IVF cycle with more than 300IU rFSH/day Less than 5 embryos | 25mg tid for 6 weeks | DHEA group: 04/16 pregnancies Control group: 2/16 pregnancies |
| Xu et al., E22014 | Retrospective | Implantation rate Clinical Pregnancy rate |
Two or more of following: ≥40years <4 oocytes recovered in previous cycle <5AFC |
25mg tid for 90 days | DHEA group: 57/189 pregnancies Control group :37/197 pregnancies |
| Vlahos et al., 2015 | Prospective | Clinical Pregnancy rate Delivery of a live born |
Two of following: ≥40years <3 oocytes recovered in previous cycle E2 peak <500pg/ml |
25mg tid for 12 weeks | DHEA group: 1/48 pregnancies in Control group 8/113 pregnancies |
| Kotb et al., 2016 | Randomized controlled trial | Clinical Pregnancy rate | Bologna criteria | 25mg tid for 3 months | DHEA group 20/70 pregnancies Control group: 9/70 pregnancies |