Figure 3. A - Representation of pronucleus transfer, where two PNs are withdrawn from the zygote with mutated mitochondria and transferred to an abnormal zygote that had its PNs previously removed. B - Representation of the maternal spindle transfer, where the spindle is removed and transferred to an oocyte in MII that had the spindle previously removed, followed by fertilization of the reconstructed oocyte (Adapted from Craven et al., 2017).