Figure 5. A - Terminal vesicle transfer representation, where the germinal vesicle I is removed and transferred to an oocyte that had its germinal vesicle previously removed, then the constructed oocyte undergoes in vitro maturation followed by fertilization. B - Plasma transfer representation, which consists of transferring from 5 to 15% of the cytoplasm content of a healthy donor to the oocyte of the patient with mutated mitochondria, followed by oocyte fertilization (Adapted from Craven et al. 2017).