Table 7. Results, secondary outcomes.
Fertilization rate G5 media Result Other media 1 Result Other media 2 Result p S/NS
Kleijkers et al., 2016 G5 62.9 HTF 69.1     <0.001 S
Zhang et al., 2016 G5 71.3 Cook sequential medium 71.0     >0.05 NS
Ceschin et al., 2016 G5 67 GV BLAST sole 67     0.59 NS
Hambiliki et al., 2011 G5 73.5 Universal IVF Medium 67.2     0.030 S
Lopéz-Pelayo et al., 2018 G5 69.11 SAGE 1-STEP 70.07     0.736 NS
Implantation rate G5 media Result Other media 1 Result Other media 2 Result p S/NS
Kleijkers et al., 2016 G5 20.2 fresh HTF 15.3 fresh     <0.001 S
Zhang et al., 2016 G5 29.0 Cook sequential medium 30.3     >0.05 NS
Hassani et al., 2013 G5 12 ISM1 15     0.16 NS
Hambiliki et al., 2011 G5 40.9 Universal IVF Medium 37.5     0.818 NS
Lopéz-Pelayo et al., 2018 G5 25.57 SAGE 1-STEP 30.16     0.520 NS
Biochemical pregnancy rate G5 media Result Other media 1 Result Other media 2 Result p S/NS
Kleijkers et al., 2016 G5 56.6 HTF 50.1     0.06 NS
Ceschin et al., 2016 G5 41.17 GV BLAST sole 38.46     0.83 NS
Hambiliki et al., 2011 G5 49.3 Universal IVF medium/EmbryoAssist 50.0     1.00 NS
Clinical pregnancy rate G5 media Result Other media 1 Result Other media 2 Result p S/NS
Kleijkers et al., 2016 G5 47.7 HTF 40.1     0.03 S
Zhang et al., 2016 G5 50.0 Cook sequential media 46.7     >0.05 NS
Hassani et al., 2013 G5 27.6 ISM1 32.1     0.23 NS
Hambiliki et al., 2011 G5 46.4 Universal IVF Medium 36.4     0.467 NS
Lopéz-Pelayo et al., 2018* G5 41.05 (37.7) SAGE 1-STEP 55.88 (49.60)     0.213 (0.357) NS
Lin et al., 2015† G5 44.43 G5 Plus 43.34 Global 41.25   S
Lin et al., 2013 G5 42.9 Global 40.8 Quinn’s advantage medium 39.3   NS
Miscarriage rate G5 media Result Other media 1 Result Other media 2 Result p S/NS
Kleijkers et al., 2016 G5 15.8 HTF 13.4     0.33 NS
Hassani et al., 2013 G5 21.1 ISM1 20.5     0.9 NS
Lopéz-Pelayo et al., 2018* G5 9.52 (9.61) SAGE 1-STEP 14.29 (16.90)     0.472 (0.266) NS
Multiple Pregnancy rate G5 media Result Other media 1 Result Other media 2 Result p S/NS
Kleijkers et al., 2016 G5 10.3 HTF 13.2     0.40 NS
Hassani et al., 2013 G5 3.8 ISM1 8.5     0.19 NS
Congenital malformations G5 media Result Other media 1 Result Other media 2 Result p S/NS
Kleijkers et al., 2016 G5 Singletons:
2.5 Major
3.7 Minor
Twins:
2.6 Major
2.6 Minor		 HTF Singletons:
Major 4.4
Minor 4.4
Twins:
4.8 Major
0.0 Minor		     0.52
0.78

1.00
0.48		 Overall NS

All results are measured in percentages.
*Without brackets: Fresh. In brackets: Numbers for cumulative fresh and frozen ICSI.
†G5 and G5 Plus compared to Global. Significantly higher clinical pregnancy rates in the G5 and G5 Plus group compared to the Global group.