| Table 1. Influence of maternal age, ovarian reserve, paternal age and seminal quality on the risk of embryonic aneuploidy. | ||||
| Euploid Group N=200 |
Aneuploid Group N=222 |
Odds Ratio (CI) | p | |
|---|---|---|---|---|
| Infertility time (years), mean (SD) | 3.0±2.5 | 3.6±3.2 | 0.041* | |
|
Maternal age (years), mean (SD)
<38 years, % >38 years, % |
33.9±3.8 56.4% 27.2% |
36.4±4.5 48.4% 72.8% |
3.4 (2.2-5.4) | <0.001* <0.001† |
| Maternal weight (kg), mean (SD) | 63.3 (7.9) | 62.6 (9.0) | 0.442* | |
| Maternal height (m), mean (SD) | 1.62 (0.06) | 1.61 (0.05) | 0.549* | |
| Maternal body mass index, mean (SD) | 24.1 (2.8) | 23.9 (3.1) | 0.557* | |
|
Antral follicle count, %
Low ovarian reserve (≤5) Intermediate ovarian reserve (6-10) Normal ovarian reserve (> 10) |
25.6% 37.3% 53.4% |
74.4% 62.7% 46.6% |
3.3 (1.5-7.0)‡ 2.2 (1.4-3.6)§ |
<0.001† |
| Paternal age (years), mean (SD) | 38.5±7.0 | 40.0±7.5 | 0.000* | |
|
Seminal collection type, % (N)
Masturbation Percutaneous epididymal sperm aspiration Testicular sperm extraction |
46.9% (189) 60.0% (9) 50.0% (2) |
53.1% (214) 40.0% (6) 50.0% (2) |
0.605† | |
| Semen concentration (106/ml)||, mean (SD) | 57.9±44.5 | 56.8±49.0 | 0.817* | |
| Semen motility (%)||, mean (SD) | 51.6±22.2 | 49.8±49.0 | 0.435* | |
| Sperm preparation 106/ml (swim-up)||, mean (SD) | 29.3±31.5 | 21.3±30.0 | 0.073* | |
SD: standard deviation
CI: confidence interval
*T-test
†Chi-squared test
‡Risk of aneuploidy: (low reserve) x (normal reserve).
§Risk of aneuploidy: (low reserve + intermediate reserve) x (normal reserve).
||Only data for semen collected by masturbation were included in this analysis.