Table 6. Predictive value, likelihood ratio, sensitivity, and specificity for diagnosis of embryo aneuploidy
  Pre-test prevalence PPVd NPV LR+ LR- Sensitivity (%) Specificity (%)
One factor
Maternal age > 38 years
Antral follicle count ≤ 5
Trophectoderm type C
Inner cell mass type C		 52.6
52.6
52.6
52.6		 72.7
72.5
70.6
60.2		 56.5
49.4
52.8
49.0		 2.4
2.4
2.1
1.4		 0.7
0.9
0.8
0.9		 44.0
14.2
32.1
22.2		 81.5
94.0
85.0
83.5
Two factors
Maternal age > 38 years + Inner cell mass type C
Maternal age > 38 years + Trophectoderm type C
Trophectoderm type C + Inner cell mass type C		 52.6
52.6
52.6		 81.8
88.6
72.2		 49.6
51.4
47.3		 4.0
7.0
2.1		 0.9
0.8
0.9		 12.0
17.4
11.3		 97.0
97.5
94.8
Three factors
Maternal age > 38 years + Trophectoderm type C + Inner cell mass type C		 52.6 85.0 48.8 5.1 0.9 7.6 98.6

PPV: Positive predictive value; NPV: Negative predictive value; LR: Likelihood ratio