Figure 4. Comparative characteristic of ERK, AKT, PTEN and PPARγ mRNAs expression in leiomyoma tissue explants and leiomyoma primary cultures cells, incubated at different progesterone concentrations (P4) Real-time PCR shows the effect of progesterone on ERK (a), AKT (b) PTEN (c) and PPARγ (d) mRNAs expression in leiomyoma tissue explants and leiomyoma primary cultures cells. Results are presented as median, first quartiles, third quartiles. *- p<0.05, ** - p<0.01, Mann-Whitney U-test with controls, xp< 0.05, xx- p<0.01, Mann-Whitney U-test with explants.