| Table 2. Multivariable GEE Logistic Regression Models with Cleavage Stage Cohorts. | ||||
| Slow (N=6,153 embryos) | Intermediate (N=13,894 embryos) | Fast (N=19,254 embryos) | p-value | |
| Adjusted OR (95% CI) * | Reference | Adjusted OR (95% CI) * | ||
| Blastulation Rate | 0.28 (0.26, 0.30) | 1.0 | 1.38 (1.29,1.48) | <0.0001 |
| Biopsied Blastocyst Rate | 0.25 (0.23, 0.28) | 1.0 | 1.42 (1.34,1.51) | <0.0001 |
| Euploid Rate | 0.93 (0.79, 1.08) | 1.0 | 1.08 (1.01,1.17) | 0.03 |
* Adjusted analyses were performed using a multivariable logistic generalized estimation equation (GEE) modeling adjusted embryo cell division speed at day 3 (cleavage stages: slow <6, intermediate 6-8, fast >8) accounting for within-correlation at the patient and cycle level, controlling for patient age, BMI, AMH, and percent embryo fragmentation.