Table 4. Association between TMSC and alterations in the 1999 and 2010 WHO classifications.
Variables TMSC (x106) P
< 20 (n=200) ≥ 20 (n=277)
1999 WHO Classification
    Total concentration < 40 million
    Concentration/ ml < 20 x 106
    Motility a + b < 50%
    Morphology < 14%
    With alterations - 4 general criteria*
    With at least 2 alterations		 161 (80.5)
154 (77.0)
178 (89.0)
177 (88.5)
200 (100)
192 (96.0)		 2 (0.7)
16 (5.8)
132 (47.7)
158 (57.0)
201 (72.6)
101 (36.5)		 <0.001
<0.001
<0.001
<0.001
<0.001
<0.001
2010 WHO Classification
    Total concentration < 39 million
    Concentration/ ml < 15 x 106
    Motility a + b < 32%
    Morphology < 4%
    With at least 1 abnormal parameter*
    With at least 2 abnormal parameters*		 160 (80.0)
140 (70.0)
129 (64.5)
46 (23.0)
193 (96.5)
108 (54.0)		 2 (0.7)
6 (2.2)
22 (7.9)
4 (1.4)
30 (10.8)
4 (1.4)		 <0.001
<0.001
<0.001
<0.001
<0.001
<0.001

*The patient had alterations in any of the four parameters: total concentration, concentration/ ml, motility and morphology TMSC: Total Motile Sperm Count; WHO: World Health Organization.