Table 3. Summary of the studies that combine Time lapse embryo culture and PGT-A analysis.
Item Reference Type of study Embryos
(n)		 Patients
(n)		 Embryo culture Day transfer Morphokinetic parameters Statistically significant
variables
significant difference no significant difference
Euploid vs. aneuploid Amir et al., 2019 cohort study 270 NA Blastocyst stage FISH x   t4,tSB, tPNf
Basile et al., 2014 Retrospective 504 125 Blastocyst stage aCGH x   t5-t2, cc3
Bayram et al., 2012 Prospective 122 17 Cleavage stage FISH x   s3
Campbell et al., 2013 Retrospective 195 25 Blastocyst stage aCGH x   tSC,tSB, tB
Chavez et al., 2012 Cohort studies 53 NA Cleavage stage aCGH x   from t1 to t4
Chawla et al., 2015 Retrospective 496 132 Blastocyst stage aCGH x   tPNf, t2, t5,cc2,cc3, t5-t2
Davies et al., 2012 Retrospective 62 NA NA aCGH x   t2,t3,s2
Del Carmen Nogales et al., 2017 Retrospective 485 112 Blastocyst stage aCGH x   t3, t5, cc2, cc3, s2, t5-t2
Hong et al., 2013 Prospective 307 24 Blastocyst stage qPCR x   tEB and from t5 to tSB
Euploid vs. aneuploid Huang et al., 2019 Retrospective 188 34 Cleavage stage aCGH x   tBE
Kahraman et al., 2020 Retrospective 741 279 Blastocyst stage aCGH x   t2,t3,t4,t5,t6,t7,t8,t9, tM, tSB, tB
Kramer et al., 2014 Retrospective 149 25 Blastocyst stage aCGH   x  
Melzer et al., 2013 Prospective             tM
Minasi et al., 2016 Retrospective 928 454 Blastocyst stage aCGH x   t4,s2,tB, tEB, tHed
Mumusoglu et al., 2017 Retrospective 415 103 Blastocyst stage aCGH x   t9,tM,tSB,tB,tEB
Patel et al., 2016 Retrospective 167 26 Blastocyst stage aCGH   x  
Rienzi et al., 2015 cohort study 455 138 Blastocyst stage aCGH   x  
Semeniuk et al., 2013 retrospective 76 NA Blastocyst stage aCGH   x  
Euploid vs. aneuploid Stevens et al., 2012 Cohort studies 53 35 Blastocyst stage qPCR   x  
Vera-Rodriguez et al., 2015 Prospective 85 NA Cleavage stage aCGH x   tPNf, t2 , s2
Yang et al., 2014 prospective 498 138 Blastocyst stage aCGH   x  
Zhang et al., 2017 Retrospective 256 75 Blastocyst stage aCGH   x  
Male vs. female Bodri et al., 2016 Retrospective 291 NA Blastocyst stage NA X   t8,tM, tB
Bronet et al., 2015 Retrospective 327 93 Blastocyst stage aCGH X   s2, tM
Huang & Jin, 2017 Retrospective 174 134 NA NA X   t3,t4,cc2
Huang et al., 2019 Retrospective 308 228 Cleavage stage NA X   t3,t4,t5, cc2
Male vs. female Melzer et al., 2013 Prospective 213 20 Blastocyst stage aCGH X   t4
Serdarogullari et al., 2014 Retrospective 177 139 NA NA   x  
Zeyad et al., 2018 cohort study 416 120 Blastocyst stage FISH X   tPN, tPNf

Note: NA: not available; d2/3/5: day 2/3/5; FISH: fluorescence in situ hybridization; aCGH: array comparative genomic hybridization; qPCR: quantitative polymerase chain reaction; other abbreviations in Table 1.