Figure 2. Histopathological changes of rat testis after treatment with Cleistanthus collinus. Testis of salinetreated rats showing normal seminiferous tubules and Sertoli cells (A, B). Arrow showing the presence of 3- 4 layers of spermatogenic cells along with mature sperm. The cyclophosphamide-treated group showed reduced spermatogenic layers, with reduced spermatocytes and spermatogonia (C,D). The Cleistanthus collinus, 200 mg/kg treated group showed rounded and degenerated sperm cells (E). The Cleistanthus collinus, 400 mg/kg treated group showed necrotic seminiferous tubules with the absence of spermatogenesis with granular debris (F). There was also giant cell formation. (H&E stain 200X & 400X).