| Table 2. Perinatal complications in IVF singletons and spontaneously conceived control population. | |||
| Perinatal outcome | AB Group (ART conception) N=1125 (%) |
SB Group (Spontaneous conception) N=7193 (%) |
p-value |
|---|---|---|---|
| Mean gestation at delivery (weeks) | 36±3 | 38±2.3 | <0.001 |
| Mean weight of new-born (gr) | 2484±724 | 2784±578 | <0.001 |
| Low birth babies (<2500 gr) | 572 (50.8%) | 2092 (29.1%) | <0.001 |
| Extreme low birth weight (<1000 gr) | 24 (2.1%) | 45 (0.6%) | <0.001 |
| Early preterm birth (<34 weeks) | 202 (18%) | 412 (5.7%) | <0.001 |
| Preterm birth (34-37 weeks) | 558 (49.6%) | 968 (13.5%) | <0.001 |
| Small for gestational age (SGA) babies | 78 (7.2%) | 448 (6.8%) | 0.05 |
| LGA babies | 137 (12.6%) | 675 (10.3%) | 0.05 |
| Chorioamnionitis | 32 (2.8%) | 3 (0.01%) | <0.001 |
| NICU admission | 172 (23.6%) | 595 (8.3%) | <0.001 |
| 1 min Apgar <7 | 113 (10.1%) | 487 (6.8%) | <0.001 |
| 5 min Apgar <7 | 43 (3.9%) | 130 (1.8%) | <0.001 |
| Supplemental oxygen | 41 (3.6%) | 519 (7.2%) | <0.001 |
| Transient tachypnoea of new-born (TTN) | 75 (6.7%) | 578 (8%) | 0.112 |
| Meconium aspiration syndrome (MAS) | 31 (2.8%) | 59 (0.8%) | <0.001 |
| Hyaline membrane disease (HMD) | 14 (1.2%) | 126 (1.8%) | 0.219 |
| Intubation | 168 (15%) | 219 (3%) | <0.001 |
| Surfactant use | 53 (4.7%) | 89 (1.2%) | <0.001 |
| Neonatal Seizures | 73 (6.5%) | 33 (0.5%) | <0.001 |
| Intraventricular Hemorrhage (IVH) | 23 (2%) | 50 (0.7%) | <0.001 |
| Hypoxic-Ischemic Encephalopathy (HIE) | 61 (5.4%) | 61 (0.8%) | <0.001 |
| Congenital malformations | 21 (2.9%) | 185 (2.6%) | 0.626 |
| Patent ductus arteriosus (PDA) | 37 (3.3%) | 33 (0.5%) | <0.001 |
| Neonatal death | 29 (2.6%) | 130 (1.8%) | 0.079 |