Figure 1. miR-181d-5p levels are increased in serum from women with high response to COS. Small RNA fractions were extracted from serum collected from women prior to COS, and were used for cDNA synthesis. cel-miR-39 was employed as a spike-in for normalization of miR-181d-5p expression values. PR, poor response, n=25; NR, normal response, n=21; HR, high response, n=20; *, p<0.05; **, p<0.01; ***, p<0.001. Each plot represents mean ± standard deviation.