Table 1

Gene	Study	Country	Ethnicity	Definition criteria	Sample size		Mean age (years)		Mean BMI (kg/m²)
Table 1. Characteristics of studies included the meta-analysis of FSHR and DENND1A gene.
Gene	Study	Country	Ethnicity	Definition criteria	PCOS	Control	PCOS	Control	PCOS	Control
FSHR	Branavan et al. (2018)	Sri Lanka	Caucasian	OM, PO, HA	55	110	24.67±0.883	33.80±0.528	26.89±0.716	25.25±0.344
	Kim et al. (2017)	South Korea	Asian	Rotterdam	377	388	28.5±4.9	28.5±4.9	22.2±4.0	20.1±2.3
	Liaqat et al. (2015)	Pakistan	Asian	Rotterdam	96	96	26.87±4.42	26.02±3.521	31.10±1.47	30.49±1.66
	Wu et al. (2014)	China	Asian	Rotterdam	215	205	30.02±4.92	31.06±4.89	24.49±4.26	22.77±3.96
	Singhasena et al. (2014)	Thailand	Asian	Rotterdam	133	132	26.6±5.3	30±10	24.3±6.1	NA
	Fu et al. (2013)	China	Asian	Rotterdam	384	768	28.3±2.2	27.7±1.8	21.55±1.25	20.45±0.75
	Gu et al. (2010)	South Korea	Asian	Rotterdam	235	128	NA	NA	22.96±3.86	20.95±2.49
	Unsal et al. (2009)	Turkey	Caucasian	Rotterdam	44	50	14.5±1.3	14.0±3.3	25.0±5.5	20.7±4.2
DENND1A	Zhu et al. (2020)	China	Asian	Rotterdam	346	225	29.52±3.97	34.38±2.29	29.69±3.14	22.03±2.35
	Xia et al. (2019)	China	Asian	Rotterdam	163	171	28.19±3.57	28.54±3.31	22.67±2.21	22.16±2.62
	Dallel et al. (2018)	Tunisia	Arab	Rotterdam	320	446	30.85±4.7	31.83±6.0	29.22±6.1	25.93±5.4
	Gammoh et al. (2015)	Bahrain	Asian	Rotterdam	191	202	28.5±5.8	26.6±6.7	29.9±6.1	26.0±5.5
	Xu et al. (2015)	China	Asian	Rotterdam	800	1110	26.5±3.6	26.8±3.8	23.5±4.3	20.4±2.2
	Eriksen et al. (2012)	Denmark	Caucasian	Rotterdam	168	248	29 (24-33)	25 (23-27)	26.2 (22.8-30.8)	23.3 (21.6-24.8)
	Welt et al. (2012)	Iceland US (Boston) US (Chicago)	Caucasian Caucasian	NIH NIH NIH	376 559 201	16947 477 188	18-45 18-45 18-45	NA 18-45 >18	NA NA NA	NA NA NA
	Welt et al. (2012)	Iceland US (Boston) US (Chicago)	Caucasian	NIH NIH NIH	376 559 201	16947 477 188	18-45 18-45 18-45	NA 18-45 >18	NA NA NA	NA NA NA
	Lerchbaum et al. (2011)	Austria	Caucasian	Rotterdam	503	311	27 (23-31)	29 (26-36)	24.2 (21.2-29.0)	24.4 (20.9-29.2)
	Lerchbaum et al. (2011)	Austria	Caucasian	Rotterdam	503	311	27 (23-31)	29 (26-36)	24.2 (21.2-29.0)	24.4 (20.9-29.2)

(FSHR - follicle stimulating hormone receptor, DENND1A - Differentially Expressed in Normal and Neoplastic Development isoform 1A, BMI - body mass index, PCOS - polycystic ovary syndrome, OM - oligomenorrhea, PO - polycystic ovaries, HA - hyperandrogenism, NA - not available, NIH - National Institutes of Health, US - United States)