| Table 1. Baseline characteristics and previous clinical outcomes (from the first cycle with GnRH antagonist protocol) in the group 1 (submitted to second GnRH antagonist protocol) versus group 2 (submitted to long GnRH agonist protocol with corifollitropin alfa followed by hMG - simplified long protocol. | |||
| Group 1 GnRH antagonist |
Group 2 Simplified long protocol |
p-value | |
|---|---|---|---|
| Number of patients/cycles, n | 88 | 66 | |
| Age (years), mean (SD) | 34.6 (3.4) | 35.6 (3.0) | 0.076 |
| BMI (kg/m2), mean (SD) | 23.9 (4.3) | 23.7 (3.6) | 0.710 |
| AMH (ng/mL), mean (SD) | 2.27 (1.01) | 1.65 (0.91) | <0.001 |
| AFC, median (IQR) | 10 (8-15) | 9 (7-12.25) | 0.014 |
| Primary infertility cause, n (%) Male Tubal Endometriosis Idiopathic Other |
27 (30.7) 22 (25) 4 (4.5) 31 (35.2) 4 (4.5) |
18 (27.3) 22 (33.3) 9 (13.6) 13 (19.7) 4 (6.1) |
0.645 0.257 0.045 0.035 0.675 |
| Poseidon subgroup a, n (%) | 13 (14.8) | 18 (27.3) | 0.056 |
| Days of stimulation, median (IQR) | 9 (8-10) | 9 (8-10) | 0.439 |
| Number of oocytes retrieved, median (IQR) | 6 (4-7) | 5 (3-6) | 0.015 |
| Number of metaphase II oocytes, median (IQR) | 4 (3-5.75) | 3 (1-4) | <0.001 |
| Embryos obtained, median (IQR) | 1 (0-2) | 0 (0-1) | <0.001 |
| Cycle cancellation, n (%) | 1 (1.1) | 3 (4.5) | 0.314 |
| Embryo transfer, n (%) | 52 (59.1) | 18 (27.3) | <0.001 |
| Embryos cryopreserved, median (min-max) | 0 (0-3) | 0 (0-1) | 0.043 |
| Positive hCG per cycle, n (%) | 7 (8.0) | 7 (10.6) | 0.571 |
| Clinical pregnancy per cycle, n (%) | 5 (5.7) | 1 (1.5) | 0.186 |
| Live birth per cycle, n (%) | 0 (0) | 0 (0) | --- |