Table 1. Studies
Study	Group of Study	Age	Methodology used	Techniques assisted by reproduction	Microbiome/ microbiota
Babu et al., 2017	200 women (84 healthy - Group and 116 infertile - group 2)	18 years to 45 years	All swabs were subjected to culture aerobics, anaerobic and fungal from routine.	Does not portray	Group 1 - was dominated by Lactobacillus followed by Micrococcus, Enterococci and Staphylococcus spp. negative coagulase. Group 2 - Candida spp., Enterococcus followed by bacilli Gram negative, like Escherichia coli.
Wee et al., 2018	31 women (16 healthy 15 infertile)	28 years to 49 years	Collection of samples vaginal, cervical and endometrial analyzed by amplification of RNA gene ribosomal 16S (rRNA) and expression endometrial from human genes selected by the reaction in chain of polymerase from transcription reverse quantitative.	Does not portray	It was observed a dominated microbiota By Lactobacillus. However, there were a trend of that women infertile had more often Ureaplasma in vagina and Gardnerella in the cervix.
Graspeuntner et al., 2018	210 women (26 women infertile, 21 women by having infertility infectious, 89 women fertile, 54 professionals of sex.	Does not portray	Were used swabs for culture bacterial conventional, swabs for PCR against C. trachomatis, N. gonorrhoeae, M. genitalium, M. hominis and U. urealitic, swabs for the sequencing of the 16S gene rRNA.	Does not portray	It was observed Lactobacillus as the most gender prominent, which declined among the women's groups infertile and professionals of sex. In contrast had an increase in genus Gardnerella and Prevotella us women's groups infertile and professionals of sex.
Bernabeu et al., 2019	31 women (in treatment of reproduction assisted)	18 years to 50 years	Samples vaginal were harvested for analyze the V3 V4 region of the 16S rRNA and so if analyze the microbiome vaginal	Fertilization in in vitro (IVF) and Stimulation Ovarian controlled and injection intracytoplasmic the of sperm (ICSI).	Points a dominated microbiota by Lactobacillus (<90% Lactobacillus spp.) and one does not dominated by Lactobacillus, where the proportion of bacteria of the genus Gardnerella exceeds 10%.
Haahr et al., 2019	120 women (submitted to fertilization in vitro)	Age average of 40 years (Detour pattern 4.3)	Samples vaginal sequenced using the region V4 of the gene RNA ribosomal 16S with grouping of clades genomics of Gardnerella vaginalis.	Fertilization in vitro (IVF)	It was observed Lactobacillus as the dominant gender, however, the highest scores of Nugent were associated with greater diversity and included highs OTU loads corresponding to G. vaginalis, A. vaginae, Sneathia bloods and Prevotella spp.
Koedooder et al., 2019	192 women (67 women What got pregnant and 125 that don't got pregnant)	20 years to 44 years	The composition of the microbiota vaginal was determined using the IS-pro technique.	Fertilization in vitro (IVF) and Stimulation ovarian controlled and injection intracytoplasmic the of sperm (ICSI).	Dominance of Lactobacillus crispatus was an important factor in prediction of pregnancy.
Fu et al., 2020	67 women (27 failed applicant of implantation and 40 group control)	33.4±3.7	Sequencing the 16S gene rRNA of microbiota vaginal	Fertilization in vitro (IVF)	It was observed a dominance of Lactobacillus in control group, in addition of that it was verified that the decrease of Lactobacillus, plays an important role in pathogenesis of failure applicant of implantation.
Zhao et al., 2020	122 women (30 women infertile and 92 women healthy)	23 years to 40 years	Analysis of composition of microbiome vaginal using sequencing of the 16S gene rRNA.	Fertilization in vitro (IVF)	Infertile women present a decrease significant in diversity and richness of the microbiome in comparison with healthy women during the period of no ovulation (phase follicular), while the microbiome
Carosso et al., 2020	15 women (submitted to techniques of reproduction assisted)	Age ≤ 42 years old	A swab vaginal and the far end tip distal of the ET catheter were analyzed using the sequencing of the gene 16 SrRNA of last generation.	Fertilization in vitro (IVF)	The relative proportion of Lactobacillus vaginal and endometrial was decreased during the fertilization cycle in vitro, with a simultaneous increase of bacteria potentially pathogenic, such as Atopobium Escherichia-Shigella and Prevotella.
Karaer et al., 2021	223 women	23 years to 39 years	The samples vaginal for identification of microbiota vaginal was carried out using sequencing last generation and categorized from according to region hypervariable V3-V4 in gene region 16S rRNA.	Fertilization in vitro (IVF)	presented dominance of Lactobacillus in vaginal microbiota.the abundance relative of Streptococcus and Gardnerella was increased in women who don’t got pregnant.
Hao et al., 2021	100 women (51 subjected to IVF, where 25 got pregnant, 49 submitted transfers of embryo, where 27 They were clinically pregnant)	20 years to 40 years old age	The regions variables 3 and 4 (V3-V4) of 16S rRNA gene were amplified and sequenced.	Fertilization in vitro (IVF)	a minor proportion of Lactobacillus for other bacteria in cervical microbiota was associated with decrease in chances of pregnancy clinic.
Sun et al., 2021	184 women	Age Reproductive	Samples vaginas, from cervix and of the cavity uterine for sequencing of 16S rRNA.	Does not portray	It was observed that the microbiota cervico vaginal was dominated by Lactobacillus.At the general, the composition of the microbiota in uterine cavity was more diverse than that in the vagina and cervix of the uterus.
Koedooder et al., 2021	85 women (in treatment of reproduction assisted)	18 years to 43 years old	The composition microbial was Determined by the reaction in chain of polymerase of V1-V3 regions of the gene bacterial 16S rRNA	Fertilization in vitro (IVF)	A decrease significant in plenty of species of Lactobacillus as well like an increase significant in the species of Staphylococcus was observed in women who got pregnant after treatment of IVF/IVF-ICSI.
Azpiroz et al., 2021	307 women (287 infertile and 20 group control)	21 years to 39 years old.	Samples of swab were collected from vagina and the straight. The composition microbial by NGS and the expression of miRNA by PCR in time real.	Fertilization in vitro (IVF)	Infertile patients showed lower bacterial richness and increase in ratio Firmicutes / Bacteroidetes in rectal level and augmentation of reason Lactobacillusbrevis / Lactobacillusiners in samples vaginal in relation to the fertile group.
Lüll et al., 2022	25 women (with infertility)	28 years to 42 years old	Analysis of sample of fabrics and fluids for sequencing of 16S rRNA.	Fertilization in vitro (IVF)	It was observed that the dominance of Lactobacillus genus is a factor important that influences the composition microbial.
Sezer et al., 2022	52 women (26 infertile and 26 fertile)	20 years to 45 years old	Samples vaginal and endometrial were analyzed by PCR quantitative in real time.	Does not portray	It was found that the microbiota in vaginal samples from patients with infertility, it was harmed as much to the number of Lactobacillus. In addition addition, it was portrayed that the women with microbiota lactobaciliary impaired had increased risk for infertility.
Villani et al., 2022	90 women (with diagnosis in infertility, 2 patients excluded, remaining 88, which 39 got pregnant and 49 negative)	24 years to 40 years old	Vaginal swabs which after the extraction of DNA microbial, the regions variables V3-V4 of the gene 16S rRNA were amplified and sequenced	Assisted reproduction’s Technologies	It was found that the plenty of Lactobacillus was favorable for positive results. In addition plenty of Lactobacillus crispatus and iners, respectively increased and decreased in the group favorable in comparison to unfavorable group.
Patel et al., 2022	31 women (11 fertile and 20 infertile, being 10 with failure appellant and 10 with infertility unexplained)	Does not portray	The samples faecal and vaginal, the regions variables V2-V3 of the gene 16S rRNA were amplified and sequenced.	Fertilization In vitro (IVF) and Injection intracytoplasmic the of sperm (ICSI)	The vaginal microbiota was dominated by genre Lactobacillus, with Lactobacillus iners being the most species abundant among the groups. Compared with the infertile cohort, the growth excessive of bacteria anaerobic, associated with dysbiosis vaginal, like Leptotrichia and Snethia, occurred in the controls.