| Table 2. Thyroid diseases and clinical outcomes in assisted reproduction | |||||||
| Thyroid
disease |
Author | Number of patients | Age/
TSH levels |
BMI (kg/m2)/
TSH levels |
Drug | Control
group |
Clinical
outcome |
|---|---|---|---|---|---|---|---|
| Thyroid autoimmunity | Zhong et al., 2012 | 90 | 32.8y | 20.5 | - | Euthyroid
(negative self-immunity) |
(IVF
+ ICSI)
↓ Fertilization; ↓ Viable embryos; ↓ Pregnancy rate |
| Tan et al., 2014 | 835 | 31.4y | 23.7 | - | Euthyroid
(negative self-immunity) |
(ICSI)
No statistical differences |
|
| Chai et al., 2014 | 122 | 35.2y | 21.1 | - | Euthyroid
(negative self-immunity) |
(IVF
+ ICSI)
No statistical differences |
|
| Unuane et al., 2016 | 333 | 33.4y | 25.2 | Levothyroxine | Euthyroid
(negative self-immunity) |
(IVF
+ ICSI)
No statistical differences |
|
| Unuane et al., 2017 | 187 | 33.83y | 23.8 | - | Euthyroid
(negative self-immunity) |
(IIU)
No statistical differences |
|
| Nacak et al., 2018 | Group IOP: n=150
ovarian aging group in old age:n=150 |
group IOP: 30.5y
ovarian aging group in advanced age:36.8y |
- | - | - | (ICSI)
group IOP:↓ Pregnancy rate |
|
| Ke et al., 2020 | 1075 | 31 | 23.4 | - | Euthyroid
(negative self-immunity) |
(IVF
+ ICSI)
↑ Congenital anomalies |
|
| Poppe et al., 2020 | 25 | 36.5 | 24.6 | - | Euthyroid
(negative self-immunity) |
(IVF
+ ICSI)
↓ Number of revored oocytes |
|
| 0.3 <TSH<2.5 mIU/L:54
2.5<TSH<4.2 mIU/L:54 |
0.3<TSH<2.5mIU/L:30.8y
2.5<TSH<4.2mIU/L:30.3y |
0.3<TSH<2.5mIU/L:23.1
2.5<TSH<4.2mIU/L:23.4 |
- | Euthyroid
(negative self-immunity) |
(ICSI)
↓ Embryo rate |
||
| Gungor & Gungor,2021 | 39 | 31.6 | 25 | - | Euthyroid
(negative self-immunity) |
(IVF)
No statistical differences |
|
| Zhuang et al., 2021 | 42 | 32.37 | 24.91 | - | Euthyroid
(negative self-immunity) |
(IVF
+ ICSI)
↑ Premature delivery |
|
| Huang et al., 2021a | 778 | 20-38 | 22.6 | - | Euthyroid
(negative self-immunity) |
(IVF
+ ICSI)
↓ Number of recovered oocytes |
|
| Hypothyroidism | Scoccia et al., 2012 | 21 | 33.3 | - | Levothyroxine | Euthyroid | (FIV)
↓ Live births; ↓ Implementation; ↓ Clinical pregnancy |
| Busnelli et al., 2013 | 137 | 35 | 22.9 | Levothyroxine* | Euthyroid
(Without Levothyroxine) |
(IVF
+ ICSI)
↑ Cancellation of cycles |
|
| Neto et al., 2016 | TSH<2.5mUI/L:455
TSH:2.5-4.0mUI/L:162 |
TSH<2.5mUI/L:35y
TSH:2.5-4.0mUI/L:35y |
TSH<2.5mUI/L:24.2
TSH:2.5-4.0mUI/L 24 |
- | Subclinical hypothyroidism | (IVF
+ ICSI)
No statistical differences |
|
| Cai et al., 2017 | 200 | 28.8 | 22.7 | LT-4 | Euthyroid | (IVF
+ ICSI)
No statistical differences |
|
| Pekman et al., 2019 | 387 | 27 | 24.4 | - | Healthy control | (IIU)
No statistical differences |
|
| Rao et al., 2021 | 229 | 36 | 24.5 | - | Euthyroid | (IVF
+ ICSI)
No statistical differences |
|
| Thyroid cancer | Huang et al., 2021b | Total thyroidectomy:26.
Partial thyroidectomy:38 |
Total thyroidectomy:34.9y
Partial thyroidectomy:33y |
Total thyroidectomy:23.3.
Partial thyroidectomy:23 |
- | Healthy control | (IVF
+ ICSI)
↓ Live births |
| Huang et al., 2021c | 64 | 33.8 | 23.1 | - | Healthy control | (IVF
+ ICSI)
↓ Number of recovered oocytes ↓ Fertilization ↓ Viable embryos |
|