| Table 1. Effects of 20 µg/ml crocin supplementation during in vitro culture on the rate of cleavage arrest and blastocyst formation of four-cell mouse embryos. | ||||||
| Intact 4-Cell Embryos | p-value | Half-Destroyed Embryos | p-value | |||
|---|---|---|---|---|---|---|
| Control (n=100) |
Crocin (n=100) |
Control (n=150) |
Crocin (n=150) |
|||
| Cleavage arrest* | 7 (7.0%) | 6 (6.0%) | 0.774 | 45 (30.0%) | 22 (14.7%) | 0.001 |
| Good-quality Blastocyst formation† | 86 (86.0%) | 89 (89.0%) | 0.521 | 56 (37.3%) | 77 (51.3%) | 0.015 |
* Cleavage arrest observed at 24 hours
† Good-quality blastocyst is defined as full + expanding + hatching/hatched blastocyst at 72 hours of culture
Chi-square tests.