Q1 = Was true randomization used for assignment of participants to treatment groups?, Q2 = Was allocation to treatment groups concealed?, Q3 = Were treatment groups similar at the baseline?, Q4 = Were participants blind to treatment assignment?, Q5 = Were those delivering the treatment blind to treatment assignment?, Q6 = Were treatment groups treated identically other than the intervention of interest?, Q7 = Were outcome assessors blind to treatment assignment?, Q8 = Were outcomes measured in the same way for treatment groups?, Q9 = Were outcomes measured in a reliable way?, Q10 = Was follow up complete and if not, were differences between groups in terms of their follow up adequately described and analysed?, Q11 = Were participants analysed in the groups to which they were randomized?, Q12 = Was appropriate statistical analysis used?, Q13 = Was the trial design appropriate and any deviations from the standard RCT design (individual randomization, parallel groups) accounted for in the conduct and analysis of the trial?, Y = Yes, N = No, U = Unclear.