| Table 1. Outline of the research problem, 2023. | |
| P | adult patients (over 18 years old) |
| I/E | diagnosis of sickle cell disease (all genotypes) |
| C | women without a diagnosis of sickle cell disease |
| O | laboratory measurement of AMH and/or antral follicle count via transvaginal or transabdominal ultrasound to assess ovarian reserve |
| S | cohort, case-control, cross-sectional study, and clinical trials |