| Table 3. Subgroup analysis for younger and older patients. | ||||||||
| Variable | rFSH, n=341 | hp-hMG, n=115 | Age<35 rFSH x hp-hMG |
Age>35 rFSH x hp-hMG |
||||
|---|---|---|---|---|---|---|---|---|
| Age<35 n=172 |
Age>35 n=162 |
p-value | Age<35 n=49 |
Age>35 n=66 |
p-value | |||
| Age(y) | 33.80±1.19 | 37.24±1.29 | <0.001 | 34.06±1.23 | 37.42±1.39 | <0.001 | 0.186 | 0.330 |
| BMI (Kg/m2) | 23.13±3.87 | 23.57±3.95 | 0.417 | 23.93±5.96 | 23.79±4.30 | 0.898 | 0.357 | 0.758 |
| Basal FSH (mUI/mL) | 7.86±2.50 | 8.18±2.89 | 0.297 | 8.41±3.91 | 8.87 (3.72) | 0.550 | 0.250 | 0.156 |
| AFC (n) | 14.65±6.44 | 12.87±5.56 | 0.02 | 13.80±7.02 | 10.29±4.69 | 0.003 | 0.467 | 0.001 |
| Ovarian stimulation duration (days) | 11.27±1.55 | 11.38±1.66 | 0.523 | 10.76±1.36 | 11.21±1.51 | 0.098 | 0.036 | 0.465 |
| GT total dose* (mIU/ML) | 2968.58±850.88 | 3349.50±948.68 | <0.001 | 3002.67±644.76 | 3457.11±870.50 | 0.003 | 0.526 | 0.316 |
| Peak E2* (pg/mL) | 2734.08±1757.38 | 2373.08±1525.09 | 0.075 | 3453.24±2150.67 | 3478.43±2735.33 | 0.610 | 0.050 | 0.008 |
| Peak P* (ng/mL) | 1.34±0.69 | 1.32±0.81 | 0.542 | 0.91±0.43 | 1.08±0.56 | 0.246 | <0.001 | 0.011 |
| Oocytes retrieved* (n) | 18.66±12.42 | 14.95±8.88 | 0.017 | 13.37±8.52 | 13.17±10.49 | 0.531 | 0.007 | 0.033 |
| MII oocytes* (n) | 14.67±10.29 | 11.74±7.52 | 0.006 | 9.78±6.33 | 9.74±7.68 | 0.707 | 0.001 | 0.029 |
| Maturaty rate(%) | 77.96±14.32 | 78.00±18.74 | 0.985 | 75.31±20.45 | 74.95±74.95 | 0.928 | 0.304 | 0.287 |
Values are presented as mean (standard deviation) or number (%). A p value of <0.05 was considered significant.
*The P value was calculated after log transformation for normal distribution.
rFSH, recombinant follicle-stimulating hormone; hp-hMG, highly purified-human menopausal gonadotropin; BMI, body mass index; FSH, follicle-stimulating hormone; AFC, antral follicle count; GT, gonadotropins; E2, estradiol; P, progesterone; MII, metaphase II
Note: Standard reference range: FSH: 1-9.2 mIU/mL