| Table 2. Baseline characteristics and Key Performance Indicators for standard IVF for all study groups. Presented for sperm prepared with density gradient centrifugation (DGC) 2017-2022, ZyMōt™ without centrifugation (Jan-Mar 2023) and ZyMōt™ with centrifugation (April 2023-May 2024). Age is presented as mean and standard deviation. | ||||
| Parameter | DGC | ZyMōt w/o centrifugation | ZyMōt with centrifugation | p-value |
|---|---|---|---|---|
| Time period | 2017-2022 | 2023, Jan-Mar | 2023, April – 2024, May | |
| Patients | 526 | 39 | 172 | - |
| Cycle number information 1st cycle (%) 2nd cycle (%) 3rd cycle or more (%) |
856 80 15.8 4.2 |
39 77.3 13.6 9.1 |
191 75.6 14.0 10.5 |
- n.s. n.s. <.05 |
| Baseline characteristics Maternal age (years) Paternal age (years) Female infertility (%) Male infertility (%) Unexplained (%) |
33.1±4.4 35.3±5.8 46.0 0.7 53.2 |
33.3±4.4 35.3±4.9 47.1 2.9 50.0 |
33.3±3.9 35.1±4.7 38.7 4.2 57.1 |
n.s. n.s. n.s. n.s. n.s. |
| Laboratory outcome COC (no) M2 (n) Maturity rate (%) 2PN 2PN fertilization rate TFF, cycles (n) TFF rate (%) Clinically useful embryos (n) Utility rate (%) |
8038 7324 91.1 4865 66.4 56 6.5 2271 46.7 |
347 293 84.4 174 59.4 6 12.8 66 37.9 |
1850 1711 92.5 1195 70.0 13 6.8 480 40.7 |
- - <.05 - <.05 - n.s. - <.05 |
| Clinical outcome Transferred embryos (n) Positive HCGs (n) Positive HCGs (%) |
1338 646 48.3 |
50 21 42.0 |
218 104 47.8 |
- - n.s. |
COC=cumulus-oocyte complex, PN=pronuclei, TFF=total failure of fertilization, n.s=non-significant.