Table 1

Authors	Participants	Treatment	Main Findings
Table 1. Main findings gathered in the present review.
Akasheh et al. (2014)	Men Group 1 Sertraline n=30 (25mg/day) (50mg/day) BT Group n=30 behavioral technique	EPPb 1 daily dose of antidepressant or control for 3 months (1 week before, shorter dosage)	Semen parameters: significant reduction in sperm concentration (105/mL) and percentage of sperm with normal morphology (p<0.05) in Group 1. There was no significant change in semen parameters in patients treated with BT. FDE^a was significantly higher in Group 1 than in the BT Group (p=0.004).
Bezerra et al. (2019)	Rats in vitro Group 1 Sertraline: (1, 3 and 10 μM) Group 2 Fluoxetine: (1, 3 and 10 μM) in vivo Group 1 Sertraline (20mg/kg) Group 2 Fluoxetine (20mg/kg)	in vitro KCL, phenylephrine or carbachol isolated distal tail of epididymis in vivo 1 daily dose of the respective antidepressant or control for 21 days	Pharmacological parameters: in vitro Groups 1 and 2 harmed the contractions induced by KCl, phenylephrine or carbachol, (> 3 μM). Group 2 (1 μM) potentiated the contractions induced by phenylephrine. in vivo Groups 1 and 2 had an increase in spontaneous contractions of the rat’s distal tail; potentiation of induced contractions were seen with phenylephrine; Testosterone: decrease in serum levels in both groups. Semen parameters: Groups 1 and 2 had decreased daily sperm production, sperm reserves in the EP^e and TTE^f in the tail of the EP^e.
Câmara et al. (2019).	Rats Group 1 Fluoxetine (20mg/kg) Group 2 GC^c	1 daily dose of antidepressant or control for 11 days	Histopathological analysis: In Group 1, the frequency of abnormal TS^d increased. The areas of TS^d and EP^e, the number of TSDA^g, DNCL^h, 17β-HSD6 activity and serum testosterone levels were significantly reduced.
Erdemir et al. (2014)	Wistar rats Group 1 Control n=8 Group 2 Sertraline n=8 (10mg/kg) Group 3 Fluoxetine n=8 (10mg/kg) Group 4 Escitalopram n=8 (10mg/kg) Group 5 Paroxetine n=8 (20mg/kg)	1 daily dose of antidepressant or control for 2 months	LHi: There were no significant differences between the Groups (p=0.092). FSHj: Level increased only in Group 2. Testosterone: With the exception of Group 3, levels were lower in all groups compared to Group 1. Group 2 had the lowest level compared to Group 1 [40.87 (22.3746.8) vs. 15.87 (13.5319.88), p<0.01]. MDA^k: There was no significant differences between the Groups (p=0.090). Histological analysis: The EJ^l was significantly lower in Group 5 compared to Group 1 (p<0.05). The negative impact of SSRIs was markedly greater in Group 5.
Galal et al. (2016)	Rats Group 1 Fluvoxamine n=12 (9mg/kg-1) low therapeutic dose Group 2 Fluvoxamine n=12 (27mg/kg-1) high therapeutic dose Group 3 AD^m n=12 (0.5ml) Group 4 Fluvoxamine n=12 high and low therapeutic dose Group 5 Fluvoxamine n=12 high and low therapeutic dose	1 daily dose of antidepressant or group 3 for 8 weeks groups 4 and 5 then left without treatment for another 8 weeks GRⁿ	Biochemicals parameters: Groups 4 and 5 had liver, kidney and heart dysfunction. Semen parameters: risk of male infertility, which is indicated by impacts on steroidogenesis hormones and harmful values in the spermogram. Histological analysis: high and low therapeutic doses also induced EO^o and ATT^p. The changes observed were reversed, mainly in GRⁿ
Ilgin et al. (2017)	Rats Group 1 Citalopram (5mg/kg) Group 2 Citalopram (10mg/kg) Group 3 Citalopram (20mg/kg)	1 daily dose of antidepressant for 28 days.	Semen parameters: Sperm concentration and normal morphology were reduced; FDE^a: increased in Groups administered CTL^q Histopathological analysis: changes in the testicles of the rats given CTL^q. LHⁱ: increased in groups administered CTL^q. Testosterone: increased in all Groups.
Mazzilli et al. (2021)	Men Group 1 Antidepressants n=6 SSRI Group 2 Benzodiazepines n=4 Group 3 Antipsychotics n=10 Group 4 Control n=10	1 daily dose of antidepressant or control for 3 months	Semen parameters: Group 1 and 3 had semen levels significantly lower than the therapeutic serum range. Sperm concentration and progressive motility were significantly reduced in Groups treated with psychotropic drugs compared to Group 4 (p=0.03). These parameters were much lower in Group 3 (p<0.05).
Monteiro Filho et al. (2014)	Female and baby rats Wistar Group 1 Fluoxetine (5 mg/kg) Group 2 Fluoxetine (10 mg/kg) Group 3 Fluoxetine (20 mg/kg)	1 daily dose of antidepressant given from the 13^th day of pregnancy to the 21^st day of lactation	Histopathological analysis: Group 3 with reduced testicular weight (16%), EP^e (28%), GS^r (18%), TS^d (17%), VTCL^t (30%), TS^d length (17%), daily sperm production (18%). increased AICL^u (7%) and plasma testosterone (49%). Other dosages led to nonsignificant changes.
Moradi et al. (2023)	Mice Group 1 Control Group 2 Citalopram (10mg/kg) Group 3 Melatonin (10mg/kg) Group 4 Melatonin (20mg/kg) Group 5 Melatonin (10mg/kg) and Citalopram (10mg/kg) Group 6 Melatonin (20mg/kg) and Citalopram (10mg/kg)	1 daily dose of antidepressant with or without melatonin, for 35 Days	Semen parameters: groups treated with melatonin had restored spermatogenesis, improved sperm count, motility, viability, morphology and chromatin integrity. Testosterone: improved substantially in Groups 5 and 6. Histopathological analysis: improved substantially in Groups 5 and 6. EO^o: increased, however, melatonin restored the antioxidant status, TAC^v levels. Decreased levels of NO^w and MDA^k in Groups 2, 5 and 6, induced an increase in the number of sperm cells positive for ET^x. Groups 5 and 6 saw lesser apoptotic effects of CTL^q
Yakubu & Jimoh (2015)	Rats Group 1 n=5 0.5 ml AD^m Group 2 Paroxetine n=5 (10mg/kg) 0.5 ml AD^m Group 3 Paroxetine n=5 (10mg/kg) 0.5 ml AD^m and 47 mg/kg extract Group 4 Paroxetine n=5 (10mg/kg) 0.5 ml AD^m and 94 mg/kg extract Group 5 Paroxetine n=5 (10mg/kg) 0.5 ml AD^m and 141 mg/kg extract	1 daily dose group 1, per 7 days 1 daily dose of antidepressant, ADm and extract, for 21 days	Biochemical parameters: groups 2, 3, 4 and 5 had reduced levels of total protein, sialic acid, glycogen, total cholesterol and testosterone (p<0.05). Testicular analysis: groups 3, 4 and 5 had reduced alkaline phosphatase and acid phosphatase activity, LD^y and GGT^z. Decreased effects with the extract, compared to Group1. Group 5 had attenuated levels of androgenic parameters when compared to Group 1.