Table 2. Comparison of embryo morphokinetic parameters between Biochemical, Positive and Negative groups (n=1248 embryos).
Morphokinetics Biochemical Group Negative Group Positive group * p -value
n 54 750 444
tPNa 5.53±0.65 a
B: -0.865 (CI: -2.227-0.496)
7.54±0.18 b
B: 1.144 (CI: 0.562 -1.726)
6.40±0.23 a <0.001
tPNf 23.47±0.81 a
B: -0.597 (CI: -2.284-1.089)
25.60±0.22 b
B: 1.528 (CI: 0.824-2.232)
24.07±0.28 a <0.001
t2 25.99±0.85 a
B: -0.584 (CI: -2.352-1.184)
28.38±0.23 b
B: 1.805 (CI: 1.067-2.542)
26.58±0.30 a <0.001
t3 36.70±0.93 a
B: -1.356 (CI: -3.283-0.571)
39.00±0.25 b
B: 0.953 (CI: 0.149-1.758)
38.05±0.32 a 0.008
t4 39.00±1.03 a
B: -0.061 (CI: -2.201-2.079)
41.57±0.28 b
B: 2.514 (CI: 1.621-3.407)
39.06±0.36 a <0.001
t5 50.46±1.21
B: -0.015 (CI: -2.214-2.484)
51.59±0.32
B: 1.120 (CI: 0.097-2.142)
50.47±0.41 0.085
t6 52.68±1.34 ab
B: -0.100 (CI: -2.880-2.680)
54.87±0.36 b
B: 2.098 (CI: 0.950-3.246)
52.78±0.46 a 0.001
t7 55.53±1.30 ab
B: 0.412 (CI: -2.282-3.106)
57.45±0.36 b
B: 2.327 (CI: 1.209-3.445)
55.12±0.44 a <0.001
t8 58.58±1.44 ab
B: 0.839 (CI: -2.149-3.828)
61.28±0.40 b
B: 3.550 (CI: 2.294-4.806)
57.74±0.50 a <0.001
tM 87.78±1.54
B: 0.323 (CI: -2.860-3.505)
88.20±0.44
B: 0.739 (CI: -0.587-2.065)
87.46±0.51 0.549
tsB 99.03±1.29
B: 1.363 (CI: -1.306-4.032)
98.58±0.38
B: 0.917 (CI: -0.229-2.064)
97.67±0.44 0.239
tB 107.93±1.23
B: 2.722 (CI: 0.173-5.271)
105.97±0.39
B: 0.765 (CI: -0.386-1.915)
105.20±0.43 0.080
cc2 10.63±0.14 a
B: -0.842 (CI: -1.279--0.405)
11.47±0.18 b
B: 1.172 (CI: 0.811-2.275)
10.70±0.50 a 0.001
cc3 13.32±0.75
B: 0.879 (CI: -0.680-2.438)
12.73±0.20
B: 0.287 (CI: -0.351-0.925)
12.44±0.26 0.448
s1 2.52±0.12 ab
B: 0.014 (CI: -0.238-0.266)
2.66±0.03 b
B: 0.156 (CI: 0.051-0.261)
2.51±0.04 a 0.012
s2 2.30±0.56 ab
B: 1.295 (CI: 0.139-2.451)
2.57±0.15 b
B: 1.561 (CI: 1.078-2.043)
1.01±0.19 a <0.001
s3 8.12±1.16 ab
B: 0.654 (CI: -1.752-3.060)
10.55±0.33 b
B: 3.090 (CI: 2.079-4.101)
7.46±0.40 a <0.001
KIDScore 5.59±0.35 a
B: -0.397 (CI: -1.133-0.340)
4.73±0.11 b
B: -1.257 (CI: -1.583--0.932)
5.99±0.13 a <0.001

Note: tPNa–timing to pronuclei appearance, tPNf–timing to pronuclei fading, t2–timing to two cells, t3–timing to three cells, t4–timing to four cells, t5–timing to five cells, t6–timing to six cells, t7–timing to seven cells, t8–timing to eight cells, tSB– timing to start blastulation, tB–timing to blastulation, s1–timing to complete t2-tPNf synchronous divisions, s2–timing to complete t4-t3 synchronous divisions, s3–timing to complete t8-t5 synchronous divisions, cc2–duration of the second cell cycle (t3-t2), cc3–duration of third cell cycle (t5-t3), KIDScore–known implantation diagnosis score. Values are the mean±- standard error, unless otherwise noted. Different superscript letters in a line represent significant differences (p<0.05). B– regression coefficient, CI–95% confidence interval. * Reference group.