| Table 2. Description of the population included by type of intervention and treatment group. | ||||||||||||
| Study | Study Design | Inclusion criteria | Treatment group | Treatment group | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N Cycles |
Age (years) |
Ovarian reserve* | Nº ET (n) | N Cycles |
Age (years) |
Ovarian reserve* |
Nº ET (n) | |||||
| Ultralong GnRH protocol | Long GnRH protocol | |||||||||||
| GnRH protocol before COS and fresh ET |
Hou |
Retrospective cohort | Infertile patients whith adenomyosis. Age<38, FSH<10, AFC>10, first IVF attemps, no PCOS, no imune diseases, no myomas, no previous myomectomy, no uterine malformations, no ednometriosis | 362 | 31.9 (30-35) |
NR | 127 | 31.8 (29-34) |
NR | NS | ||
|
Chen |
Retrospective cohort | Infertile patients with adenomyosis | 52 | 33.5 (31-36.75) |
2 (2-3) |
162 | 33.5 (30-36.75) |
2 (2-3) |
NS | |||
|
Lan |
Retrospective cohort | Infertile patients whith adenomyosis. Age<42, no myomas, no previous uterine surgery, no uterine malformations, no untreated hydrosalpinx | 237 | 33.55±4.12 | 2.37 (1.35-4.17) |
2.05±0.57 | 134 | 33.99±4.08 | 1.93 (1.13-4.18) |
2.05±0.55 | NS | |
|
Wu |
Retrospective cohort | Infertile patients whith adenomyosis. Age<42, no submucosal myoma or myoma<2cm, no previous uterine surgery, no uterine malfromatios, no untreated hydrosalpix, <3 attemps on ET | 259 | 33.35±4.16 | 8.09±3.74 | 2.01±0.54a | 115 | 33.88±4.13 | 1.95±0.5a | 0.11a | ||
|
Ge |
Retrospective cohort | Infertile patients whith adenomyosis. Age<42, no intrauterine lesions, no uterine malformations, no untreated hydrosalpinx | 108 | 34 (31-37) |
1.65 (1.06-3.03)b |
NR | 56 | 32.5 (30-36) |
NR | 0.11b | ||
|
Park |
Retrospective cohort | Infertile patients whith adenomyosis, excluding other causes of infertility other than adenomyosis | 150 | 35.2±3.5 | 2.9±1.1 | 147 | 36.1±3.3 | 2.7±1.1 | NS | |||
|
Ge |
Retrospective cohort | (see above) | 162 | 34 (31-37) | 1.65 (1.06-3.03) |
NR | 34 | 33.5 (32-41) | 1.32 (0.92-3.37) |
NR | NS | |
|
Ge |
Retrospective cohort | (see above) | 56 | 32.5 (32-1) |
2.75 (1.66-390) |
NR | 34 | 33.5 (32-41) |
1.32 (0.92-3.37) |
NR | NS | |
| Short GnRH protocol | Antagonist GnRH protocol | |||||||||||
|
Ge |
Retrospective cohort | (see above) | 59 | 33.5 (32-41) |
1.30 (0.77-1.90) |
NR | 34 | 33.5 (32-41) |
1.32 (0.92-3.37) |
NR | NS | |
|
Niu |
Retrospective cohort | Infertile patients with adenomyosis, Age <38, ≤ 1 previous FET, normal uterine cavity, no previous myomectomy, no untreated hydrosalpinx, no stage IV endometriosis | 194 | 32.11±4.02 | 1.96±.04 | 145 | 31.52±4.03 | 1.94±0.37 | NS | |||
|
Zhang |
Retrospective cohort | Infertile patients with adenomyosis. Age ≤45, uterine volume between 56-100cm3, no endocrine or autoimmune disorders, normal kariotype in both partners, normal uterine cavity (no intrauterine adhesions, no submucosal myomas or myomas <50mm) | 45 | 33.5±3.7 | 3.36± | 1.48±0.6 | 218 | 34.8±4.7 | 3.50±2.9 | 1.49±0.6 | NS | |
|
Li |
Retrospective cohort | Infertile patients with adenomyosis. Age <45, no uterine malformations, no endometriosis, no untreated hydrosalpinx, no PCOS, normal kariotype in both partners | 160 | 35.56±4.49 | 1.11±0.19 | 181 | 35.25±4.95 | 1.12±0.21 | NS | |||
* Ovarian reserve: AMH expressed in ng/ml or basal FSH in italics and expressed in mlU/ml when AMH was not available; PCOS = Polycystic Ovarian Syndrome.