Figure 1. Relative expression fold change of CLDN3 at 3 different treatment times (A: 24 hr, B: 48 hr, and C: 72 hr). Gene expression results are normalized to β-actin mRNA amplification. A: * vs. control (p=0.003); # vs. 50nM (p=0.014); Ø vs. control and 50nM (p=0.002); B: * vs. control and 200nM (p=0.002); C: * vs. control (p=0.04); D: CLDN3 expression process within each group through study course; 200nM (* vs. 48h (p=0.009), # vs. 72h (p=0.05).