Figure 8. Relationship between patient age and glutathione markers in blood and follicular fluid. (A) Significant negative correlation between disulfide glutathione (GSSG) levels in blood and patient age, suggesting a diminished ability to recycle GSH into GSSG with increasing age. (B) Significant negative correlation between the GSSG/GSH ratio in blood and patient age, indicating a decline in the efficiency of systemic redox balance as women age. (C) Significant negative correlation between GSSG levels in follicular fluid and patient age, reflecting a reduction in local antioxidant capacity within the follicular microenvironment with advancing age. r=Spearman’s correlation coefficient. Significant differences are noted when p-value<0.05.