Table 1. Diagnostic criteria and treatment for chronic endometritis according to different studies.
Study and year of publication Hysteroscopy performance time Number of plasma cells considered for diagnostic criteria Antimicrobial treatment
Bouet et al., 2016 Follicular phase (between days 6 and 12) ≥ 5 plasma cells per 10 HPFs Doxycycline 100 mg orally twice a day for 14 days
Zargar et al., 2020 3-5 days after menstruation; HC staining evaluation using anti sundecan-1 (CD 138) ≥ 5 plasma cells per 20 HPFs Doxycycline 100 mg orally twice a day for 21 days
Rimmer et al., 2021 Secretory stage (certified by transvaginal ultrasound scan between days 4-14 post positivity of LH strips) ROC analysis suggests an overall good performance for CD138+ as a diagnostic test with scores above a cutoff value of 4-6 cells/HPF Not evaluated
Gay et al., 2021 Not described ≥ 1 plasma cell (s) per HPFs Antibiotic adapted to antibiogram, or doxycycline (100 mg twice a day) plus metronidazole (500 mg twice a day) orally for 14 days
Takimoto et al., 2023 Mid-luteal phase, confirmed by transvaginal ultrasound and the last menstrual cycle Liu’s method (Plasma cell count > 5.15/10 mm2), McQueen scores and plasma cell count/10 mm2 Not evaluated
McQueen et al., 2014 Not described H&E >1 plasma cell inthe whole section Ofloxacin 400 mg + metronidazole 500 mg orally twice a day for 14 days Or doxycycline +/- metronidazole or ciprofloxacin + metronidazole
Cicinelli et al., 2014 Follicular phase of menstrual cycle > 1 plasma cell/ HPFs Gram-negative: ciprofloxacin 500 mg twice/day for 10 d. Gram-positive: amoxicillin + clavulanate 1 g twice/day for 8d. Mycoplasma or U urealyticum: josamicine: 1 g twice/day for 12d. Negative culture: ceftriaxone 250 mg i.m. + doxycycline 100 mg orally twice/day for 14d + metronidazole 500 mg orally twice/day for 14 d (CDC guidelines)
McQueen et al., 2015 Not described 1-5 plasma cells per HPF, or discrete clusters of <20 plasma cells by CD138 staining. Doxycycline 100 mg twice a day for 14 or 21 days according to physician preference

HPF: high power fields; LH: luteinizing hormone.