Table 2. Diagnostic criteria for Post-Orgasmic Illness Syndrome, adapted from Waldinger et al. (2011)
Requirement	Description
Requirement 1	One or more of the following symptoms must be present: flu-like manifestations, muscle weakness, excessive fatigue, mood changes or irritability, memory impairment, eye pruritus, disorganized speech, nasal congestion, feverish sensation, or difficulty concentrating.
Requirement 2	Symptoms appear immediately (within seconds), shortly thereafter (minutes), or within a few hours after ejaculation, whether following sexual intercourse, masturbation, or spontaneous nocturnal emission.
Requirement 3	Symptoms occur after more than 90% of ejaculation events.
Requirement 4	Symptoms persist for 48 hours to 7 days.
Requirement 5	Symptoms disappear spontaneously almost always.