| Table 2. List of SNPs correlated with ovarian response | |||||||||||
| SNP | Chromosome Location | Nearest Gene | Gene Remarks | Minor Allele | Minor Allele Frequency | Odds Ratio | (95% CI)
|
||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hypo-response group | Normo-/hyper response group | ||||||||||
| rs870849 | 12: 6,777,854 | Missense, CDS variant | T | 0.3725 | 0.1708 | 4.07 | (2.065, 8.024) | 5.04E-05 | |||
| rs283815 | 19: 44,887,076 | Intron variant | G | 0.3824 | 0.1777 | 3.685 | (1.925, 7.055) | 7.30E-05 | |||
| rsl57582 | 19: 44,892,962 | Intron variant | T | 0.3725 | 0.1736 | 3.683 | (1.91, 7.104) | IE-04 | |||
| rs4485511 | 2: 141,401,398 | Intron variant | c | 0.6373 | 0.3926 | 3.226 | (1.829, 5.69) | 5.19E-05 | |||
| rsl2458598 | 18: 13,238,716 | Intron variant | A | 0.598 | 0.343 | 2.954 | (1.759, 4.961) | 4.25E-05 | |||
| rsl2458598 | 18: 13,238,716 | 2KB Upstream Variant | A | 0.598 | 0.343 | 2.954 | (1.759, 4.961) | 4.25E-05 | |||
| rs3109350 | 2: 141,339,231 | Intron variant | C | 0.5686 | 0.2893 | 2.868 | (1.762, 4.467) | 2.22E-05 | |||
| SNP | Chromosome Location | Nearest Gene | Gene Remarks | Minor Allele | Minor Allele Frequency | Continuous variable | Beta Coefficient | Beta Coefficient (95% CI) | |||
| Hypo-response group | Normo-/ hyper response group | ||||||||||
| rs4485511 | 2: 141,401,398 | LRP1B | Intron variant | C | 0.6373 | 0.3926 | Mature oocyte | -3.38 | (-4.863, -1.897) | 1.44E-05 | |
| AFC | -2.386 | (-3.69, -1.082) | 0.0004375 | ||||||||
| AMH | -0.8236 | (-1.529, -0.1179) | 0.02341 | ||||||||
| rs8085876 | 18: 50,093,778 | MY05B | Intron variant | G | 0.3787 | 0.3605 | Mature oocyte | -3.28 | (-4.795, -1.765) | 3.62E-05 | |
| AFC | -1.549 | (-2.904, -0.1936) | 0.02639 | ||||||||
| AMH | -0.8891 | (-1.605, -0.173) | 0.01599 | ||||||||
| rs7235513 | 18: 50,109,096 | MY05B | Intron variant | A | 0.3566 | 0.3517 | Mature oocyte | -3.215 | (-4.719, -1.71) | 4.51E-05 | |
| AFC | -1.639 | (-2.98, -0.2974) | 0.01773 | ||||||||
| AMH | -0.8349 | (-1.546, -0.1235) | 0.02266 | ||||||||
Note: threshold p value: 3E-06; CDS: Coding DNA Sequence, KB: kilobases; CI: confidence interval