Table 2. List of SNPs correlated with ovarian response
SNP Chromosome Location Nearest Gene Gene Remarks Minor Allele Minor Allele Frequency Odds Ratio (95% CI) p
Hypo-response group Normo-/hyper response group
rs870849 12: 6,777,854 LAG3 Missense, CDS variant T 0.3725 0.1708 4.07 (2.065, 8.024) 5.04E-05
rs283815 19: 44,887,076 NECTIN2 Intron variant G 0.3824 0.1777 3.685 (1.925, 7.055) 7.30E-05
rsl57582 19: 44,892,962 TOMM40 Intron variant T 0.3725 0.1736 3.683 (1.91, 7.104) IE-04
rs4485511 2: 141,401,398 LRP1B Intron variant c 0.6373 0.3926 3.226 (1.829, 5.69) 5.19E-05
rsl2458598 18: 13,238,716 LDLRAD4 Intron variant A 0.598 0.343 2.954 (1.759, 4.961) 4.25E-05
rsl2458598 18: 13,238,716 C18orfl5 2KB Upstream Variant A 0.598 0.343 2.954 (1.759, 4.961) 4.25E-05
rs3109350 2: 141,339,231 LRP1B Intron variant C 0.5686 0.2893 2.868 (1.762, 4.467) 2.22E-05
SNP Chromosome Location Nearest Gene Gene Remarks Minor Allele Minor Allele Frequency Continuous variable Beta Coefficient Beta Coefficient (95% CI) p
Hypo-response group Normo-/ hyper response group
rs4485511 2: 141,401,398 LRP1B Intron variant C 0.6373 0.3926 Mature oocyte -3.38 (-4.863, -1.897) 1.44E-05
AFC -2.386 (-3.69, -1.082) 0.0004375
AMH -0.8236 (-1.529, -0.1179) 0.02341
rs8085876 18: 50,093,778 MY05B Intron variant G 0.3787 0.3605 Mature oocyte -3.28 (-4.795, -1.765) 3.62E-05
AFC -1.549 (-2.904, -0.1936) 0.02639
AMH -0.8891 (-1.605, -0.173) 0.01599
rs7235513 18: 50,109,096 MY05B Intron variant A 0.3566 0.3517 Mature oocyte -3.215 (-4.719, -1.71) 4.51E-05
AFC -1.639 (-2.98, -0.2974) 0.01773
AMH -0.8349 (-1.546, -0.1235) 0.02266

Note: threshold p value: 3E-06; CDS: Coding DNA Sequence, KB: kilobases; CI: confidence interval