| Table 3. Pattern of utilization of follitropin delta in Brazil – Gonadotropins | ||||
| Variable | Oocyte donors (n=131) |
Oocyte cryopreservation (n=705) |
IVF (n=1448) |
All patients (n=2284) |
|---|---|---|---|---|
| Prescription based on algorithm - n (%) · Yes · No |
0 131 (100%) |
17 (2.4%) 688 (97.6%) |
26 (1.8%) 1422 (98.2%) |
43 (1.9%) 2241 (98.1%) |
| Starting daily dose maintained or modified based on algorithm (Protocol 1 only) - n (%) · Maintained · Increased · Diminished |
N/A N/A N/A |
12 (70.6%) 2 (11.8%) 3 (17.6%) |
21 (80.8%) 3 (11.5%) 2 (7.7%) |
34 (79.1%) 3 (7.0%) 6 (14.0%) |
| Starting dose of follitropin delta (µg) · Protocol 1 · Protocol 2 · Protocol 3 · Protocol 4 · Protocol 5 |
12.4 (2.4) N/A 13.6 (2.1) 11.8 (2.1) N/A 14.6 (2.5) |
10.1 (2.7) 9.5 (1.8) 12.0 (2.9) 9.5 (2.4) 10.8 (1.7) 11.0 (3.1) |
10.3 (2.7) 8.2 (2.1) 12.4 (3.1) 9.9 (2.5) 11.1 (2.3) 9.9 (3.4) |
10.3 (2.7) 8.7 (2.1) 12.3 (3.0) 9.9 (2.5) 11.0 (2.1) 11.4 (2.7) |
| Total dose of follitropin delta (µg) · Protocol 1 · Protocol 2 · Protocol 3 · Protocol 4 · Protocol 5 |
117.0 (25) N/A 135.3 (21.9) 109.6 (20.3) N/A 142.7 (26.8) |
96.6 (30.9) 86.7 (20.1) 116.2 (33.1) 89.6 (27.2) 116.1 (29.2) 107.3 (37.6) |
96.9 (29.2) 81.8 (20.3) 115.3 (33.3) 93.3 (26.7) 110.2 (32.8) 92.8 (31.9) |
97.9 (29.8) 83.7 (20.1) 116.4 (33) 93.2 (26.8) 112.4 (31.5) 110.5 (30.8) |
| Starting dose menotropin or recombinant FSH+LH (IU) · Protocol 3 · Protocol 4 |
89 (41) N/A |
137 (38) 142 (55) |
128 (42) 138 (59) |
128 (42) 140 (57) |
| Total dose of menotropin or recombinant FSH+LH (IU) · Protocol 3 · Protocol 4 |
810 (307) N/A |
1294 (438) 1577 (715) |
1210 (451) 1443 (585) |
1210 (453) 1496 (640) |
Data are presented as mean±standard deviation (SD).
Protocol 1 (algorithm)
Protocol 2 (non-algorithm monotherapy)
Protocol 3 (delta + hMG)
Protocol 4 (delta + rFSH/LH)
Protocol 5 (others)
N/A: Not applicable (None of the oocyte-donor patients underwent treatment with
Protocol 1 or Protocol 4).