| Table 4. Cycle characteristics and laboratory outcomes according to stimulation protocol and overall IVF cohort (n=1,448) | ||||||
| Variable | Protocol 1 n=26 |
Protocol 2 n=195 |
Protocol 3 n=1126 |
Protocol 4 n=70 |
Protocol 5 n=31 |
IVF overall n=1448 |
|---|---|---|---|---|---|---|
| Age (years) | 34.0±3.3 | 35.1±4.0 | 37.5±3.8 | 38.4±3.1 | 37.0±4.9 | 37.1±3.9 |
| Weight (kg) | 62.4±14.0 | 66.8±11.7 | 65.4±11.8 | 64.8±9.6 | 65.5±8.3 | 65.5±11.7 |
| Partner age (years) | 36.7±4.5 | 39.1±6.6 | 39.9±5.9 | 39.8±5.2 | 40.0±8.3 | 39.7±6.0 |
| AMH (ng/mL) | 5.6±6.2 (n=26) | 5.0±4.5 (n=106) | 1.8±1.7 (n=871) | 2.0±2.0 (n=51) | 1.4±1.2 (n=20) | 2.2±2.6 (n=1073) |
| AFC | 21.9±8.2 | 17.1±9.8 | 11.1±6.8 | 10.3±5.6 | 12.6±10.5 | 12.2±7.8 |
| Duration of stimulation (days) | 10.2±2.3 | 9.6±1.5 | 9.9±1.6 | 10.5±1.6 | 10.7±2.2 | 9.9±1.7 |
| Oocytes retrieved (n) | 14.9±7.7 | 15.3±9.3 | 11.1±8.2 | 9.3±6.2 | 11.7±10.0 | 11.7±8.4 |
| MII oocytes (n) | 10.6±4.6 | 11.8±7.9 | 8.4±6.2 | 7.3±5.1 | 8.5±7.5 | 8.8±6.5 |
| Injected oocytes (n) | 10.6±4.6 | 10.5±6.0 | 8.2±5.5 | 7.2±4.9 | 8.1±7.4 | 8.5±5.7 |
| Normally fertilized 2PN (n) | 8.4±4.0 | 7.8±4.9 | 6.1±4.5 | 5.5±4.2 | 6.3±6.4 | 6.4±4.6 |
| Blastocysts (n) | 4.9±3.1 | 5.0±3.7 | 3.4±3.2 | 3.0±3.4 | 3.6±4.8 | 3.7±3.4 |
| Top-quality blastocysts (n) | 3.8±2.6 | 3.4±2.7 | 2.2±2.4 | 2.3±2.8 | 1.9±2.8 | 2.4±2.5 |
| Biopsied embryos (n) | 5.0±2.4 | 4.9±3.2 | 3.4±3.0 | 2.8±2.9 | 3.3±3.6 | 3.5±3.0 |
| Euploid embryos (n) | 2.5±2.0 | 2.1±1.9 | 1.2±1.6 | 1.0±1.5 | 1.4±2.2 | 1.3±1.6 |
| Ongoing pregnancy (%) - 1st embryo transfer | 39.1% (9/23) | 49.5% (50/101) | 51.6% (285/552) | 33.3% (9/27) | 58.3% (7/12) | 50.3% (360/715) |
Data are presented as mean±standard deviation (SD).
Protocol 1 (algorithm)
Protocol 2 (non-algorithm monotherapy)
Protocol 3 (delta + hMG)
Protocol 4 (delta + rFSH/LH)
Protocol 5 (others)
AMH = anti-Müllerian hormone
AFC = antral follicle count
MII = metaphase II oocytes
2PN = two pronuclei