| Table 6. Effect of PGT on the delivery rate and miscarriage rate according to age of women in autologous FET and OD FET (2022) | ||||
| Age of women | FET with PGT | FET without PGT | PR (95% CI); p-value | |
|---|---|---|---|---|
| Delivery* | Oocyte Donors | 38.0% (823/2167) | 35.7% (3287/9204) | 0.94 (0.89; 1.00); 0.060¥¥ |
| Autologous <35 |
40.2% (536/1333) | 36.6% (2845/7770) | 0.91 (0.84; 0.98); 0.008¥¥ | |
| Autologous 35 - 39 |
39.6% (1079/2724) | 30.6% (3255/10,654) | 0.77 (0.73; 0.81); <0.001¥¥ | |
| Autologous >39 |
38.0% (807/2125) | 24.1% (1779/7393) | 0.63 (0.59; 0.68); <0.001¥¥ | |
| Miscarriage* | Oocyte Donors | 15.3% (160/1046) | 15.8% (680/4310) | 1.02 (0.87; 1.20); 0.773¥ |
| Autologous <35 |
12.1% (84/695) | 16.6% (634/3817) | 1.36 (1.10; 1.69); 0.004¥ | |
| Autologous 35 - 39 |
12.3% (175/1419) | 19.1% (871/4571) | 1.54 (1.33; 1.80); <0.001¥ | |
| Autologous >39 |
13.2% (137/1038) | 21.4% (551/2572) | 1.62 (1.37; 1.93); <0.001¥ | |
FET, frozen embryo transfer; OD FET = oocyte donation frozen embryo transfer; PGT, preimplantation genetic testing; PR, prevalence ratio.
All analyses were adjusted for women’s age.
(*) For miscarriage the denominator are clinical pregnancies, for deliveries, the denominator are embryo transfers without LFU.
¥ Likelihood of having a miscarriage. The reference group is “with PGT”.
¥¥ Likelihood of delivery. The reference group is “with PGT”.