JBRA Assisted Reproduction 2025;29(Suppl.2 SBRA 2025):251
Poster Presentation
29^th Annual Congress of the SBRA. São Paulo/SP - Brazil, 2025
doi: 10.5935/1518-0557.20263830

P-239. Treatment of chronic endometritis in women with repeated implantation failure: a systematic review

Mariana Alcantara Feres¹, Rachel Araujo Gonçalves Coelho¹, Bruno Ramalho Carvalho¹

¹ Faculdade de Ciências da Educação e Saúde do Centro Universitário de Brasília (FACES/CEUB) – Brasília – DF - Brasil

Objective: To investigate and gather data on reproductive outcomes after antibiotic treatment in women with chronic endometritis.
Methods: This was a systematic literature review, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, including clinical trials, randomized controlled trials, observational studies, and metaanalyses. Data were extracted and synthesized using the Synthesis Without Meta-analysis guidelines.
Results: After evaluating the studies included in this review, it was noted that the preferred treatment regimen consisted of oral administration of doxycycline 100 mg twice daily for 14 days, combined with other antibiotics (metronidazole, ciprofloxacin, levofloxacin, moxifloxacin, or azithromycin) or not. However, there is no consensus regarding the choice of antibiotic, nor the need for confirmation of cure after treatment with a second biopsy. Finally, literature suggests that antibiotic treatment may have a beneficial effect on the reproductive outcomes of women with repeated embryo implantation failure, considering live birth rates.
Conclusion: Chronic endometritis is a potentially treatable cause of repeated implantation failure. Establishing a universal diagnostic protocol, with well-defined methods and appropriate antimicrobial treatment, could ultimately help thousands of infertile women and couples seeking to conceive. For now, antibiotic therapy with doxycycline, whether or not combined with other antibiotics, may improve the chance of a live birth, in the specific population.