JBRA Assisted Reproduction 2025;29(Suppl.2 SBRA 2025):211
Poster Presentation
29^th Annual Congress of the SBRA. São Paulo/SP - Brazil, 2025
doi: 10.5935/1518-0557.20263872

P-199. Reproductive outcomes of the egg sharing program: a retrospective cohort study

Fábio Vieira Vilela¹, Daniele de Novais Alves¹, Thais Oliveira Teixeira¹, Clara Pimenta de Oliveira Carneiro¹, Genevieve Marina Coelho¹

¹ Instituto Valenciano de Infertilidade (IVI) – SALVADOR – BA - Brasil

Objective: Evaluating clinical reproductive results of the cycles of patients who participated in the egg sharing program and compare the outcomes between of egg share donors and egg share recipients.
Methods: Retrospective cohort study in which in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment cycles were analyzed using fresh oocytes from the egg sharing program at a private reproductive medicine center in Salvador-Bahia from December 2018 to March 2021. The patients were divided into 2 groups: egg sharing donors cycles (group 1) and egg sharing recipients cycles (group 2). In the study were included the first embryo transfer comparing clinical reproductive results between the groups. Cycles that used vitrified eggs, frozen semen, donated semen and surgical sperm recovery techniques were excluded from the study as well as biochemical pregnancies. The following variables were verified: women's age range, body mass index (BMI), number of mature eggs retrieved (MII), number of embryos transferred, embryo quality, type of endometrial preparation, endometrial thickness, presence of uterine pathologies; seminal quality (Kruger morphology) of the partners of egg donors and recipients. Seminal quality was classified according to Kruger morphology as normal (≥4%), mild alteration (2-4%) and severe (≤1%).
Results: During the study period, 117 ICSI cycles from the egg sharing program were screened which 34 were excluded. 83 cycles were included in the study according to the pre-defined inclusion criteria, 38 cycles corresponding to group 1 and 45 cycles in group 2. In the general analysis of the data, it was observed that the average maternal age was 31.6 years in donors and 42.8 years (±3.5) in recipient, which 33.3% had a BMI ≥25kg/m² (average BMI group 2: 24.5±3.9). A total of 575 matured eggs were recovered, with an average of 6.9 MII per case. A total of 143 embryos were transferred, 78.9% of which were double embryo transfers (DET) in group 1 and 66.6% in group 2. The transfer rate of vitrified embryos in egg share donors cycles was 81.5% and only 13.3% in recipients, whereas the transfer rate of fresh embryos was higher in recipients (86.6%) than in donors (18.4%). Embryos classified as good quality were observed in 89.4% of donor cycles and 93.3% of recipient cycles. The most used endometrial preparation protocols in all cycles were with hormonal therapy (97.3%) and the average endometrial thickness achieved in group 1 was 8.7mm; with a similar result in group 2 (8.4mm). Uterine pathologies were found more in recipients than donors (37.7% vs. 23.6%). Regarding seminal quality, serious changes were evident in most partners, especially in donor partners (71% vs. 55%). The following clinical reproductive outcomes were obtained in the egg share donors and recipients cycles respectively: clinical pregnancy rates (53% vs. 51%), implantation rates (36% vs. 43%).
Conclusion: This study showed that through the egg sharing program, a considerable number of good quality embryos were obtained, which resulted positively in the clinical pregnancy rate of both groups studied. However, the implantation rate was lower in donors cycles than in recipients cycles. This may be related with a higher frequency of DET in egg share donors cycles, in addition to a higher percentage of seminal changes. Therefore, prospective studies with more homogeneous groups and the inclusion of other variables, such as the cumulative live birth rate will be necessary for a broader evaluation of these reproductive results.