| Table 1. TRUST-PAPER | ||
| Domain | Points | Primary focus |
|---|---|---|
| A. Question, protocol and prespecification | 10 | Question, hypothesis, registration and analytic prespecification |
| B. Design, population and comparator | 10 | Design-question alignment, eligibility, representativeness and comparator |
| C. Intervention/exposure integrity | 8 | Reproducibility, misclassification, co-interventions, timing/dose/technique |
| D. Outcomes and denominators | 14 | Patient-important outcomes, correct denominator, clustering and ART integrity |
| E. Bias/confounding control | 12 | Randomization or confounding control, ascertainment and selection |
| F. Statistical methods | 14 | Effect measures, model, precision, multiplicity, clustering and reproducibility |
| G. Missingness/analysis population | 8 | Attrition, missing data, ITT/per-protocol and post-treatment exclusions |
| H. Robustness/reproducibility | 8 | Sensitivity analyses, alternative models, influential cases and replication |
| I. Clinical relevance/effect size/safety | 8 | Absolute effects, clinical importance, benefit-harm-burden and applicability |
| J. Conclusions/transparency | 8 | Conclusion-estimand alignment, proportional language, limitations/conflicts |
Note: ART, assisted reproductive technology; ITT, intention-to-treat