| Supplementary Appendix S2. PCC-PAPER
anchors |
| Item |
Dimension |
Score anchor (0-2) |
| P1 |
Clinical relevance |
2 definitive patient-important outcome1 relevant surrogate plus definitive data0 intermediate only |
| P2 |
Precision and magnitude |
2 precise and clinically meaningful1 moderate0 wide uncertainty/no useful effect |
| P3 |
Internal validity and robustness |
2 low bias and stable1 limitations0 major bias/instability |
| P4 |
Information size |
2 adequately powered/event-rich1 moderate0 sparse/underpowered |
| P5 |
Replication and applicability |
2 independent confirmation/high applicability1 limited0 isolated/poor applicability |