JBRA Assist. Reprod. 2025;29(Suppl 1):3-3
ORAL PRESENTATION
doi: 10.5935/1518-0557.20250061
O-03. Is it possible to unravel the mysteries of early miscarriages in patients undergoing in vitro fertilization using 3D ultrasound, hysteroembryoscopy, and molecular analysis? Real-Life Experiences in a Fertility Clinic
1Inmater Fertility Clinic. Lima. Peru
2Clinica La Floresta Lima Peru
Objective: To evaluate the usefulness of integrating 3D ultrasound, hysteroembryoscopy, and molecular analysis in diagnosing the causes of early pregnancy loss in patients undergoing in vitro fertilization (IVF).
Methods: A retrospective case series was conducted at Inmater Fertility Clinic (Lima, Peru), including three patients with early pregnancy loss between January and August 2024. All cases were assessed with 3D ultrasound for anatomical anomalies, hysteroembryoscopy for direct embryonic visualization and tissue sampling, and molecular analysis (PGT-A and products of conception [POC]) for chromosomal abnormalities.
Results: Table 1Case 1 involved a 36-year-old IVF patient with a euploid male embryo (46XY). A 9-week embryo with amniotic band syndrome and decapitation was identified.Case 2, a 46-year-old patient with donor eggs (PGT-A 46XX), had an umbilical cord cyst; POC analysis revealed 69XXX triploidy.Case 3 was a 38-year-old with a spontaneous pregnancy. 3D ultrasound revealed an abdominal cystic structure, and hysteroembryoscopy identified a yolk sac megavesicle. Trisomy 15 was found in the POC. These findings underscore the diagnostic power of combining imaging and genetic analysis.
Conclusion: Integrating 3D ultrasound, hysteroembryoscopy, and molecular diagnostics enhances the identification of both structural and chromosomal causes of miscarriage in IVF patients. This approach supports better reproductive planning and reduces emotional distress by clarifying the etiology of pregnancy loss.
Table 1.