JBRA Assist. Reprod. 2025;29(Suppl 1):12-13
POSTER PRESENTATION
doi: 10.5935/1518-0557.20250069

P-001. Does maternal age impact the pregnancy rate in egg donation IVF cycles?

Pilar Chuquillanqui¹, Nancy Sotero¹, José Luis Llanos¹, Fernando Peña¹, Ernesto Escudero Velando¹, Mario Ascenzo Battistini¹, Marcelo Velit¹

¹Inmater Fertility Clinic, Lima, Peru

Objective: To determine the effect of the recipient’s age on clinical pregnancy in egg donation IVF cycles.
Methods: This was a retrospective observational study of egg donation IVF cycles with preimplantation genetic testing (PGT-A) using donors aged 22 to 28 years. Data was collected from January to December 2024 at Inmater Fertility Clinic, including 408 embryo transfers with PGT-A from egg donation cycles. Inclusion criteria consisted of transfers of a euploid embryo from day 5 or 6, with either modified natural or artificial endometrial preparation and an endometrial thickness of ≥5 mm. Exclusion criteria included a clinical record of two or more failed embryo transfers. Patients were divided into two age groups: under 45, 45 and older. Clinical pregnancy rates and miscarriage rates were analyzed and compared between groups. Statistical analysis was performed using Student’s t-test for quantitative variables and the chi-squared test and F-distribution for categorical variables.
Results: A total of 268 recipients met the inclusion criteria: 180 were in the under-45 group and 88 in the 45-and-older group. Among patients aged 45 and older, no cases of endometrial preparation with a modified natural cycle were observed, likely due to most being postmenopausal. The average endometrial thickness in both groups was 9.4 mm. The pregnancy rate was 62.22% in patients under 45 and 62.5% in those 45 and older. No significant differences were found between the two groups in pregnancy rate (p=0.964) or miscarriage rate (p=0.371).Tables 1 and 2.
Conclusion: Our study, using euploid embryos, concludes that the recipient’s age does not impact the clinical pregnancy rate in egg donation IVF cycles.

 

Table 1. Clinical characteristics and IVF outcomes of the study population.

 

 

Table 2. Comparison of clinical characteristics and IVF outcomes between receptor age groups.