| Table 1. Results according to cases of PGT-M for HLA-typing. | |||||
| HLA only | HLA with monogenic disorder |
Autosomal dominant |
Autosomal recessive |
X-linked disorder |
|
|---|---|---|---|---|---|
| Number of PGT-M cycles | 6 (4%) | 62 (96%) | 1 (1.6%) | 51 (82.3%) | 10 (16.1%) |
| Number of embryos analyzed | 35 | 434 | 1 | 388 | 45 |
| HLA-matched Unaffected for the disease Affected for the disease |
22.9%(8/35) - - |
25.8% (112/434) 17.2% (75/434) 37 |
1 100% (1/1) - |
100 16.8%(65/388) 35 |
11 20% (9/45) 2 |
| Non-HLA matched embryos Unaffected for the disease Affected for the disease |
74.3%(26/35) - - |
70.0%(304/434) 200 104 |
- - - |
70.4%(273/388) 178 95 |
68.9%(31/45) 22 9 |
| Incomplete/inconclusive diagnosis | 1 | 18 | - | 15 | 3 |
| TRANSFERABLE EMBRYOS (HLA-matched (unaffected) and euploid) |
8.6% (3/35) | 11.5% (50/434) | 1 | 10.8% (42/388) | 15.5% (7/45) |
| Maternal age | 37.4 | 34.6 | 26.0 | 35.2 | 32.5 |