| Table 1. Case report summary of fertility preservation and reproductive outcomes in transmasculine individuals. |
| Author's name and year of publication |
Study population |
Time on hormone therapy |
Ovarian response |
Recovered and vitrified eggs |
Ovarian quality |
Fertilization rate |
Blastocyst formation |
Pregnancy rate |
|
Moravek
et al
. (2023)
|
26-year-old transmasculine individual |
3 years and 8 months |
AMH: 8 ng/ml, AFC: 23, Stimulation: 16 days |
14 eggs retrieved, 13 mature |
- |
9/13 (69%) |
2 blastocysts biopsied and cryopreserved |
1 blastocyst transferred, live birth |
|
Moravek
et al
. (2023)
|
34-year-old transmasculine individual |
10 years |
AMH: 9 ng/ml, AFC: No data, Stimulation: No data |
23 cryopreserved
eggs, 14 fertilized |
- |
14/23 (61%) |
8 cryopreserved blastocysts |
No transfers made so far |
|
Resende
et al
. (2020)
|
34-year-old transmasculine individual |
2 years |
No data, Stimulation: 12 days |
16 eggs retrieved, 12 mature |
- |
12/12 (100%) |
5 cryopreserved
blastocysts, 1 transferred |
Confirmed pregnancy |
|
Hassan
et al
. (2022)
|
21-year-old transmasculine individual |
2 years |
No data, Stimulation: No data |
No stimulation performed |
- |
- |
- |
Spontaneous pregnancy, cesare-an birth |
|
Minotti
et al.
(2022)
|
16 trans men,
average age 22 |
6-12 months |
AMH: 2.89 ng/ml |
- |
- |
- |
- |
- |
|
Morong
et al
. (2022)
|
Adult transgender population |
- |
- |
- |
- |
- |
- |
- |
|
Yaish
et al
. (2021)
|
Adult transgender men |
Up to 12 years old |
- |
- |
- |
- |
- |
4 transgender men have fathered 7 biological children |
|
Marschalek
et al
. (2020)
|
20 transgender men |
In hormone therapy |
No data |
No data |
Vital cells |
- |
- |
- |
|
Amir
et al
., (2020a)
|
9 trans men compared to 39 cis women |
Before starting hormone therapy |
Average AFC: 19.2 |
There was no significant difference between the two groups |
- |
- |
- |
- |
|
Amir
et al
., (2020b)
|
12 transgender men,
6 without exposure to testosterone and 6 with exposure |
Between 1 and 12 years old |
Average AFC: 16.5 |
Ova retrieved average: 23 Only one patient vitrified oocytes: 11MII |
- |
Average: 57.5% |
Average: 47.78% |
Only one patient had ongoing successful pregnancy data |
|
Leung
et al
. (2019)
|
26 Transmasculine individuals |
- |
- |
19,9 ± 8,7 |
- |
- |
- |
7 couples had transfers, obtaining live births |
|
De Roo
et al
. (2017)
|
40 Transmasculine individual |
More than a year |
- |
34.30% of oocytes in metaphase II were obtained |
- |
- |
- |
- |
|
Chen
et al.
(2017)
|
13 transgender teen-agers (7 trans women and 6 trans men) |
- |
- |
Only one patient cryopreserved oocytes |
- |
- |
- |
- |
|
Armuand
et al
. (2017)
|
15 Adult transgender men referred for fertility preservation |
- |
- |
On average 11 oocytes per individua |
- |
- |
- |
- |