Table 1. GnRH antagonist versus GnRH-a (long protocol and fl are-up) : cycle cancellation rate due to poor response
Trail GnRHantagonist GnRHagonist %Weights Odds ratio 95% CI
Long protocol
Cheunget al., 2005 10/31 11/32 21.8 0.90 (0.27, 2.94)
Marciet al., 2005 1/30 4/30 11.5 0.22 (0.004, 2.51)
D’Amato et al., 2004 4/85 20/60 66.6 0.098 (0.023, 0.32)
Pooled odds ratio = 0.29 (0.1479 to 0.569)Fixed effects (Mantel-Haenszel, Robins-Breslow-Greenland) Chi2 (test odds ratio differs from 1) = 13.5 p = 0.0002Non-combinability of studiesBreslow-Day = 8.47 (df=2) p = 0.0145 Cochran Q = 8.05 (df=2) p = 0.0179
Flare-up
Akmanet al., 2001 2/24 2/24 14.3 1.00 (0.07,14.94)
Malmusi et al.,2005 7/25 6/30 30.7 1.55 (0.37, 6.63)
Schmidt et al.,2005 10/24 12/24 54.9 0.71 (0.19, 2.57)
Pooled odds ratio = 1.014 (0.468 to 2.19)Fixed effects (Mantel-Haenszel, Robins-Breslow-Greenland) Chi2 (test odds ratio differs from 1) = 0.025 p = 0.87Non-combinability of studiesBreslow-Day = 0.8175 (df=2) p = 0.6645 Cochran Q = 0.8132 (df=2) p = 0.6658