Table 2. GnRH antagonist versus GnRH-a (long protocol and fl are-up) : number of oocyte retrieved
Trial GnRHantagonist mean±sd GnRHagonist mean±sd Mean diff 95% CI(fixed)
Long protocol
Cheunget al., 2005 19 5.89±3.02 21 5.62±4.17 0.27 (-2.0, 2.54)
Marciet al., 2005 29 5.6±1.6 26 4.3±2.2 1.3 (0.29, 2.30)
D’Amato Et al., 2004 81 5.56±1.13 40 3.36±1.3 2.2 (1.74, 2.65)
Fixed effects (Mulrow-Oxman) Pooled effect size Z (test WMD + differs from 0) = 9.21 p<0.0001Non-combinability / Cohran Q = 4.75 (df=2) p = 0.09 WMD = 1.98 (1.56 to 2.40)
Flare-up
Akman et al. 2001 20 4.5±1.8 20 5.5±2.0 -1 (-2.18. 0.18)
Malmusiet al., 2005 18 2.5±1.2 24 3.5±1.4 -1 (-1.80, -0.19)
Schmidtet al., 2005 13 8.9±0.9 11 9.0±1.2 -0.1 (-0.94, 0.74)
Fixed effects (Mulrow-Oxman) pooled effect size Z (test WMD + differs from 0) = -2.51 p = 0.0118Non-combinability / Cohran Q = 2.65 (df=2) p = 0.26 WMD = -0.67 (-1.19 to -0.15)