| Table I. Results of bivariate analysis and multiple logistic regression analyses comparing endometriosis patients with controls. | ||||
| Outcome | Endometriosis | Control | Crude OR (95% CI) | Adjusted ORa (95% CI) |
|---|---|---|---|---|
| All patientsb (n _ 2,909) | ||||
| Pregnancy rate | 25.42 | 29.52 | 0.81 (0.72-0.91) | 0.63 (0.51-0.77) |
| Fertilization rate | 59.69 | 65.94 | 0.95 (0.94-0.95) | 0.87 (0.85-0.88) |
| Implantation rate | 12.72 | 18.08 | 0.86 (0.85-0.87) | 0.86c (0.85-0.88) |
| Mean no. of oocytes | 7.81 | 7.30 | 1.06 (1.04-1.08) | 0.92 (0.85-0.99) |
| Peak E2 | 3545.04 | 4399.93 | N/A | N/A |
| Endometriosis only vs. tubal | ||||
| factor onlyd (n _ 2,893) | ||||
| Pregnancy rate | 25.38 | 27.71 | 0.88 (0.79-1.00) | 0.56 (0.44-0.70) |
| Fertilization rate | 59.50 | 66.09 | 0.95 (0.94-0.95) | 0.81 (0.79-0.83) |
| Implantation rate | 12.72 | 18.08 | 0.86 (0.85-0.88) | 0.86c (0.85-0.88) |
| Mean no. of oocytes | 7.79 | 7.30 | 1.06 (1.04-1.08) | 0.82 (0.75-0.90) |
| Peak E2 | 3545.04 | 4399.93 | N/A | N/A |
| Stage I-IIe (n _ 2,602) | ||||
| Pregnancy rate | 21.11 | 27.71 | 0.70 (0.56-0.87) | 0.79 (0.60-1.03) |
| Fertilization rate | 58.38 | 66.09 | 0.93 (0.92-0.94) | 0.94 (0.93-0.96) |
| Implantation rate | 11.31 | 18.08 | 0.80 (0.78-0.82) | 0.88 (0.85-0.90) |
| Mean no. of oocytes | 8.19 | 7.30 | 1.11 (1.06-1.14) | 0.56 (0.49-0.65) |
| Peak E2 | 5813.38 | 4399.93 | N/A | N/A |
| Stage III-IVf (n _ 2,575) | ||||
| Pregnancy rate | 13.84 | 27.71 | 0.42 (0.31-0.57) | 0.46 (0.28-0.74) |
| Fertilization rate | 74.47 | 66.09 | 1.08 (1.06-1.10) | 1.54 (1.39-1.70) |
| Implantation rate | 10.23 | 18.08 | 0.75 (0.72-0.79) | not interpretable |
| Mean no. of oocytes | 6.70 | 7.30 | 0.94 (0.91-0.98) | not interpretable |
| Peak E2 | 1447.74 | 4399.93 | N/A | N/A |
Note: P_.001 comparing endometriosis with control group in every outcome category. N/A _ not applicable.
a Adjusted for stimulation regime, publication date, and age except where noted.
b Includes endometriosis patients with other concurrent infertility factors; controls include all factors except endometriosis.
c Adjusted for publication date and age.
d Includes only endometriosis patients (all stages) with no other infertility factors, controls are tubal factor only.
e Compares stages I–II endometriosis patients with tubal factor controls. f Compares stages III–IV endometriosis patients with tubal factor controls.
Barnhart. IVF in endometriosis-associated infertility. Fertil Steril 2002.