Received October 11, 2020
Accepted April 15, 2021

It is well known that female reproduction ability decreases during forth decade of life due to age-related changes in oocyte quality and quantity; although the number of women trying to conceive has now a day remarkably increased between the ages of 36 to 44. The causes of reproductive aging and physiological aspect of this phenomenon are still elusive. With increase in the women's age, during Assisted Reproductive Technologies (ART) we have realised a significant decline in the number and the quality of retrieved oocyte as well as ovarian follicle reserved. This is because of increased aneuploidy due to factors such as spindle apparatus disruption; oxidative stress hypothesis and mitochondrial damage. The aim of this review paper is to survey data on the potential role of aging process impacting oocyte quality and female reproductive ability. We present the current evidences that show the decreased oocyte quality with age related reduction in female reproductive outcome. The aging process is complicated and it is caused by many factors that control cellular and organism life span. Although the factors responsible for reduced oocyte quality remain unknown, the present review focuses on the potential role of ovarian follicle environment, oocyte structure and its organelles. To find a way to optimize oocyte quality and ameliorate clinical outcomes for women with aging related causes of infertility.