Received October 28, 2021
Accepted May 01, 2022

Objectives: Assisted Reproductive Technology (ART) has made great strides in the forty-year but no medical treatment comes without side effects. Despite several studies reporting high incidences of perinatal complications, the association is inconclusive. Also, effect of racially and ethnically distinguished Asian population undergoing ART on perinatal outcomes is not well studied. Therefore this study attempts to compare various perinatal outcome parameters in ART and spontaneously conceived singleton pregnancies from a single high volume tertiary care centre. Methods: A retrospective cohort study from a single tertiary infertility centre was conducted from January 2011 to September 2020. The study included 1125 IVF conceived babies (AB group) and 7193 spontaneous conceived babies (SB group). The groups were compared using Pearson Chi-square test and adjusted odds ratio calculated using multivariate analysis. Results: Majority of perinatal complications like preterm birth (PTB), early preterm birth, low birth weight (LBW), extremely low birth weight, small for gestational age, large for gestational age babies, neonatal intensive care unit (NICU) admission, need for surfactant, meconium aspiration syndrome, neonatal seizures, intraventricular haemorrhage, hypoxic-ischemic encephalopathy, and patent ductus arteriosus was significantly increased in AB group as compared to the SB group (p <0.05). IVF independently increases the risk of LBW(aOR 2.530; 95% CI 2.194-2.917), PTB (aOR 4.004; 95% CI 3.496-4.587), NICU admission (aOR 2.003; 95% CI 1.610-2.492) and neonatal seizures (aOR 9.805; 95% CI 5.755-16.706). Conclusions: All ART conceived pregnant patients should receive antenatal counselling regarding perinatal complications and should deliver at a tertiary care centre with appropriate NICU support.