Juliana Fabrícia Cuzzi, Tania Vulcani de Freitas, Priscila Motta, Mark Hughes, Péricles Assad Hassun Filho
JBRA Assist. Reprod. 2011; 15 (3):29-31
Received July 19, 2022
Accepted December 02, 2022
Abstract
Objective: Aneuploidy is the principal genetic factor affecting reproductive success in humans. A great number of morphologically normal embryos either do not implant or spontaneously abort early in pregnancy because their chromosome number deviates from the normal diploid 46.
Methods: The present study used comparative genomic hybridization by microarrays (aCGH), a molecular cytogenetic method that allows simultaneous
enumeration of all chromosomes to establish a review of a full aneuploidies screening in FIV embryos.
Results: The present study illustrates that aneuploidy can affect any chromosome with a slightly higher prevalence of monosomies, suggesting that good quality embryos revealed that even the most severe chromosomal abnormalities (e.g. monosomy, imbalance affecting the largest chromosomes and aneuploidy affecting multiple chromosomes) were often capable of surviving up to the blastocyst stage.
Conclusion: Our results confirm that even though some women of advanced reproductive age can produce embryos capable of becoming blastocysts, they have an elevated risk of carrying chromosome errors compared with embryos from younger women.
