Raphaela P dos Santos, Joji Ueno, Mariana Angelozzi de Oliveira, Luciana Francisco Semião, Ricardo M de Oliveira, Ciro Dresch Martinhago
JBRA Assist. Reprod. 2011; 15 (4):35-37
Received April 20, 2011
Accepted May 27, 2011
Abstract
Objective: To verify if the A1298C polymorphism in the MTHFR gene is or not associated with a decrease of the ovarian reserve. Methods: Samples of peripheral blood were obtained from 164 female patients and MTHFR genotypes were compared to the anti-mullerian hormone as well as FSH, LH and inhibin B.
Results: Samples were divided as follows; 84 samples of non-carriers for the A1298C polymorphism in the MTHFR gene, e.g. 1298AA; 62 heterozygous 1298AC for the mutation; and 18 presented variation in homozygous form, e.g. 1298CC. The AMH mean value measured for 1298AA genotype was of 1,14 ng/mL: for the 1298AC genotype was of 0,91 ng/mL; and for the 1298CC genotype was of 1,49 ng/mL. A negative correlation between AMH and FSH, LH and the FSH/LH relationship was observed as expected. Inhibin B, on the other, presented a positive association with AMH, also as expected.
Conclusion: This study showed that by itself the A1298C polymorphism does not seem to affect AMH levels.
